Center for Computational and Theoretical Biology

Matthäus, Franziska (J. Prof.)

Franziska Matthäus

Group Leader

 Group Leader of the 

New workgroup website: 



Research Text here.


2017[ to top ]
  • TCCA: An R package for the identification of differentially expressed genes in time course microarray data. Albrecht, M.; Stichel, D.; M{ü}ller, B.F.; Merkle, R.; Sticht, C.; Gretz, N.; Klingm{ü}ller, U.; Breuhahn, K.; Matth{ä}us, F. In BMC Bioinformatics, 18, bl Art. no. 33. 2017.
  • An individual-based model for the collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors. Stichel, D.; Middleton, A.M.; M{ü}ller, B.F.; Depner, S.; Klingm{ü}ller, U.; Breuhahn, K.; Matth{ä}us, F. In NPJ Systems Biology and Applications, 3, bl Art. no. 5. 2017.
  • Modeling cellular systems. Graw, F.; Matth{ä}us, F.; Pahle, J. In Contributions in Mathematical and Computational Sciences 11. Springer, 2017.
2015[ to top ]
  • Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells. M{ü}ller, B.; Bovet, M.; Yin, Y.; Stichel, D.; Malz, M.; Middleton, A.; Ehemann, V.; Schmitt, J.; Muley, T.; Meister, M.; Herpel, E.; Singer, S.; Warth, A.; Schirmacher, P.; Drasdo, D.; Matth{ä}us, F.; Breuhahn, K. In J. Pathol., 237, bll 390–401. 2015.
2014[ to top ]
  • A hybrid model for E. coli chemotaxis: from signaling pathway to pattern formation. Matthäus, F. In Managing complexity, reducing perplexity. Modeling biological systems. Eds. G. Ajmone-Marsan and M. Delitala. Springer, 2014.
  • Does body shaping influence brain shape? Habitual physical activity is linked to brain morphology independent of age. Demirakca, T.; Brusniak, W.; Tunc-Skarka, N.; Wolf, I.; Meier, S.; Matth{ä}us, F.; Schulze, T.G.; Ende, G.; Diener, C. In World Journal of Biological Psychiatry, 15(5), bll 387–396. 2014.
  • Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol. Tunc-Skarka, N.; Meier, S.; Demirakca, T.; Sack, M.; Weber-Fahr, W.; Brusniak, W.; Wolf, I.; Matth{ä}us, F.; Schulze, T.G.; Diener, C.; Ende, G. In NMR in Biomedicine, 27(2), bll 228–234. 2014.
  • Gene expression in superior temporal cortex of schizophrenia patients. Sellmann, C.; Pildaín, L. Villarín; Schmitt, A.; Leonardi-Essmann, F.; Durrenberger, P.; Spanagel, R.; Arzberger, T.; Kretzschmar, H.; Zink, M.; Gruber, O.; Herrera-Marschitz, M.; Reynolds, R.; Falkai, P.; Gebicke-Haerter, P.J.; Matth{ä}us, F. In European Archives of Psychiatry and Clinical Neuroscience, 264(4), bll 297–309. 2014.
2013[ to top ]
  • Circadian rhythms investigated on the cellular and molecular levels. Gebicke-Haerter, P. J.; Pildaín, L. Villarín; Matth{ä}us, F.; Schmitt, A.; Falkai, P. In Pharmacopsychiatry, 46(1), bll S22-S29. 2013.
  • A systems medicine research approach for studying alcohol addiction. Spanagel, R.; Durstewitz, D.; Hansson, A.; Heinz, A.; Kiefer, F.; K{ö}hr, G.; Matth{ä}us, F.; N{ö}then, M.M.; Noori, H.R.; Obermayer, K.; Rietschel, M.; Schloss, P.; Scholz, H.; Schumann, G.; Smolka, M.; Sommer, W.; Vengeliene, V.; Walter, H.; Wurst, W.; Zimmermann, U.S.; Stringer, S.; Smits, Y.; Derks, E.M. In Addiction Biology, 18(6), bll 883–896. 2013.
  • Contextual social cognition impairments in schizophrenia and bipolar disorder. Baez, S.; Herrera, E.; Pildaín, L. Villar’in; Theil, D.; Gonzalez-Gadea, M.L.; Gomez, P.; Mosquera, M.; Huepe, D.; Strejilevich, S.; Vigliecca, N.S.; Matthäus, F.; Decety, J.; Manes, F.; Ibanez, A. In PLoS One, 8(3), bl e57664. 2013.
  • New measurement criteria for studying alcohol drinking and relapse in rodents. Pildaín, L. Villarín; Vengeliene, V.; Matth{ä}us, F. In In Silico Pharmacology, 1, bl Art. no. 13. 2013.
  • Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration. Schmitt, S.; Safferling, K.; Westphal, K.; Hrabowski, M.; M{ü}ller, U.; Angel, P.; Wiechert, L.; Ehemann, V.; M{ü}ller, B.; Holland-Cunz, S.; Stichel, D.; Harder, N.; Rohr, K.; Germann, G.; Matth{ä}us, F.; Schirmacher, P.; Grabe, N.; Breuhahn, K. In PLoS One, 8(9), bl e75075. 2013.
2012[ to top ]
  • Advances in Systems Biology, Advances in Experimental Medicine and Biology 736. Curk, T.; Matthäus, F.; Brill-Karniely, Y.; Dobnikar, J. I. Goryanin, A. Goryachev (reds.). Springer, 2012.
  • SCN1A alters brain structure and modulates age-dependent alterations in cortical activation during a working memory task. Meier, S.; Demirakca, T.; Brusniak, W.; Wolf, I.; Liebsch, K.; Tunc-Skarka, N.; Nieratschker, V.; Witt, S.; Matth{ä}us, F.; Ende, G.; Flor, H.; Rietschel, M.; Diener, C.; Schulze, T.G. In Biological Psychiatry, 72(8), bll 677–683. 2012.
  • Effects of age on the structure of functional connectivity networks during episodic and working memory demand. Matthäus, F.; Schmidt, J.-P.; Banerjee, A.; Schulze, T.G.; Demirakca, T.; Diener, C. In Brain Connectivity, 2(3), bl DOI: 10.1089/brain.2012.0077. 2012.
2011[ to top ]
  • On the origin and characteristics of noise-induced Lévy walks of E. coli. Matthäus, F.; Mommer, M.S.; Curk, T.; Dobnikar, J. In PLOS One, 6(4), bl e18623. 2011.
  • Structural analysis of functional connectivity related to memory reveals network changes in memory function over the life span. Matth{ä}us, F.; Schmidt, J.-P.; Demirakca, T.; Diener, C. In BMC Neurosci., Vol. 12 (Suppl 1), bl P71. 2011.
2010[ to top ]
  • An integrated genome research network for studying the genetics of alcohol addiction. Spanagel, R.; Bartsch, D.; Brors, B.; Dahmen, N.; Deussing, J.; Eils, R.; Ende, G.; Gallinat, J.; Gebicke-Haerter, P.; Heinz, A.; Kiefer, F.; J{ä}ger, W.; Mann, K.; Matth{ä}us, F.; N{ö}then, M.; Rietschel, M.; Sartorius, A.; Sch{ü}tz, G.; Sommer, W.H.; Sprengel, R.; Walter, H.; Wichmann, E.; Wienker, T.; Wurst, W.; Zimmer, A. In Addiction Biology, 15, bll 369–379. 2010.
  • Systems Biology and Psychiatry. Matthäus, F.; Smith, V. A.; Gebicke-Haerter, P. J. F. Tretter, P. J. Gebicke-Haerter, G. Winterer, E. Mendoza (reds.). Wiley, Weinheim, 2010.
2009[ to top ]
  • The spread of prion diseases in the brain - models of reaction and transport on networks. Matthäus, F. In J. Biol. Sys., 17(4), bll 623–641. 2009.
  • Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Matthäus, F.; Smith, V. A.; Fogtman, A.; Sommer, W. H.; Leonardi-Essmann, F.; Lourdusamy, A.; Reimers, M. A.; Spanagel, R.; Gebicke-Haerter, P. J. In Pharmacopsychiatry, 42, bll S118-S128. 2009.
  • E. coli superdiffusion and chemotaxis - search strategy, precision and motility. Matthäus, F.; Jagodi{’c}, M.; Dobnikar, J. In Biophys. J., 97(4), bll 946–957. 2009.
  • A comparison of modeling approaches for the spread of prion diseases in the brain. Matth{ä}us, F. In Studies in Computational Intelligence, 180, bll 109–117. 2009.
2008[ to top ]
  • Biosynthetic potentials of metabolites and their hierarchical organization. Matthäus, F.; Salazar, C.; Ebenhöh, O. In PLOS Comp. Biol., 4(4), bl rt. no. e1000049. 2008.
2006[ to top ]
  • Compound clustering and consensus scopes of metabolic networks. Matth{ä}us, F.; Salazar, C.; Ebenh{ö}h, O. In InterJournal Complex Systems, bl Art. no. 1674. 2006.
  • Diffusion versus network models as descriptions for the spread of prion diseases in the brain. Matthäus, F. In J. Theo. Biol., 240, bll 104–113. 2006.
2005[ to top ]
  • Hierarchical modeling of prion spread in brain tissue. Technical Report (PhD dissertation), . Matthäus, F. PhD dissertation. Polish Academy of Science, 2005.
2004[ to top ]
  • The {SI}-model for prion infection on networks. Matthäus, F. In Proceedings of the Tenth National Conference on Applications of Mathematics in Biology and Medicine, Święty Krzyż. 2004.
  • Mathematical models of prion spread in the brain and applications to the mouse visual system. Matthäus, F. In Mathematical Approach to Nonlinear Phenomena; Modelling, Analysis and Simulations. 2004.