Preimplantation development is key to mammalian pregnancy success. About 70% of pregnancies fail during the first few days before the embryo is ready for implantation. During the preimplantation phase, the fertilized oocyte divides several times to separate into three distinct populations of cells that will give rise to the embryo proper, the placenta and the yolk sac cells.
In this project, we investigate the complex and highly dynamic process of cell decision and cell pattering in the preimplantation mouse embryo. Based on the experimental data from our collaborators Dr. S. Muñoz-Descalzo (ULPGC, Gran Canaria, Spain) and Dr. C. Schröter (MPI Molecular Physiology, Dortmund), we use a combination of three-dimensional image analysis and three-dimensional mathematical modelling.