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THE BIOCENTER OF THE UNIVERSITY OF WÜRZBURG

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NEAT1 is genome-protective in human U2OS cells. Accumulation of NEAT1 at DNA double-strand breaks (NGS data, top) and defects in DNA damage signaling in NEAT1-deficient cells (merged confocal imaging data, bottom).

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team at the University of Würzburg has now gained new insights into the DNA damage response.

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The current cover photo of “Aging Cell” - here is an excerpt - refers to the Würzburg study.

Numerous studies have shown that the older the father, the higher the risk of disease for the offspring. Human geneticists at the University of Würzburg have now taken a closer look at the processes responsible for this.

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 The common carder bee (Bombus pascuorum) feeding on the large-flowered hemp-nettle (Galeopsis speciosa) in the Austrian Alps. If it gets too hot, the insects can hardly detect the scents of the flowers.

It's not just us humans who suffer from heatwaves. Researchers at the University of Würzburg discovered that hot temperatures rob bumblebees of their sense of smell – and makes them struggle when searching for food.

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Chlamydiae are sexually transmitted pathogens that can apparently survive in the human gut for a long time. Researchers from Würzburg and Berlin report this in the journal PLOS Pathogens.

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No other animal in the world has a genome as large as the South American lungfish (Lepidosiren paradoxa).

An international research team has sequenced the largest genomes of all animals – those of lungfish. The data will help to find out how the ancestors of land vertebrates managed to conquer the mainland.

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Christian Hof is head of the new Chair of Global Change Ecology at the University of Würzburg. His research focuses on how climate change and human activities affect species and biodiversity.

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The transition from the esophagus to the stomach is a delicate region from a medical point of view, often associated with pathological disorders leading to cancer. An international research team has now gained new insights into this region. These pave the way for new prevention and treatment options.

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In their natural environment, wild bees are exposed to various pesticides that can have a potentially toxic effect. A study by the University of Würzburg has now shown that bumblebees are relatively resistant to these products.

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