Department of Botany I - Plant-Physiology and Biophysics


Publication List Prof. Thomas Müller

2024[ to top ]
  • Vaz, D.C., Rodrigues, J.R., Loureiro-Ferreira, N., Müller, T.D., Sebald, W., Redfield, C., and Brito, R.M.M. (2024) Lessons on protein structure from interleukin-4: All disulfides are not created equal, Proteins, 92(2), 219–235, available:
2023[ to top ]
  • Thomas, S., Fiebig, J.E., Kuhn, E.-M., Mayer, D.S., Filbeck, S., Schmitz, W., Krischke, M., Gropp, R., and Mueller, T.D. (2023) Design of Glycoengineered IL-4 Antagonists Employing Chemical and Biosynthetic Glycosylation, ACS omega, 8(28), 24841–24852, available:
  • Steiert, F., Schultz, P., Hoefinger, S., Mueller, T.D., Schwille, P., and Weidemann, T. (2023) Insights into receptor structure and dynamics at the surface of living cells, Nature Communications, 14(1596), 15, available: 10.1038/s41467-023-37284-4.
  • Hedrich, R., Müller, T.D., Marten, I., and Becker, D. (2023) TPC1 vacuole SV channel gains further shape – voltage priming of calcium-dependent gating, Trends in Plant Science, 28(6), 673–684, available:
  • Swinerd, G.W., Alhussini, A.A., Sczelecki, S., Heath, D., Mueller, T.D., McNatty, K.P., and Pitman, J.L. (2023) Molecular forms of BMP15 and GDF9 in mammalian species that differ in litter size, Scientific reports, 13(1), 22428–22428, available:
2022[ to top ]
  • Siverino, C., Fahmy-Garcia, S., Mumcuoglu, D., Oberwinkler, H., Muehlemann, M., Mueller, T., Farrell, E., van Osch, G.J.V.M., and Nickel, J. (2022) Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 ({BMP}2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo, International Journal of Molecular Sciences, 23(7), 3928, available:
  • Bertho, S., Herpin, A., Jouanno, E., Yano, A., Bobe, J., Parrinello, H., Journot, L., Guyomard, R., Muller, T., Swanson, P., McKinney, G., Williamson, K., Meek, M., Schartl, M., and Guiguen, Y. (2022) A nonfunctional copy of the salmonid sex-determining gene (sdY) is responsible for the “apparent” XY females in Chinook salmon, Oncorhynchus tshawytscha, G3 (Bethesda, Md.), 12(2), jkab451-, available:
2021[ to top ]
  • Lehmann, J., J{o}rgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., and Maierhofer, T. (2021) Acidosis-induced activation of anion channel {SLAH}3 in the flooding-related stress response of Arabidopsis, Current Biology, 31(16), 3575–3585.e9, available:
  • Heinks, T., Hettwer, A., Hiepen, C., Weise, C., Gorka, M., Knaus, P., Mueller, T.D., and Loidl-Stahlhofen, A. (2021) Optimized expression and purification of a soluble BMP2 variant based on in-silico design, Protein Expression and Purification, 186, 105918, available:
  • Imarazene, B., Du, K., Beille, S., Jouanno, E., Feron, R., Pan, Q., Torres-Paz, J., Lopez-Roques, C., Castinel, A., Gil, L., Kuchly, C., Donnadieu, C., Parrinello, H., Journot, L., Cabau, C., Zahm, M., Klopp, C., Pavlica, T., Al-Rikabi, A., Liehr, T., Simanovsky, S.A., Bohlen, J., Sember, A., Perez, J., Veyrunes, F., Mueller, T.D., Postlethwait, J.H., Schartl, M., Herpin, A., Rétaux, S., and Guiguen, Y. (2021) A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus, Current Biology, 31(21), 4800–4809.e9, available:
  • Lehmann, J., Jørgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., and Maierhofer, T. (2021) Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis, Current Biology, available:
2020[ to top ]
  • Lauffer, P., Miranda-Laferte, E., van Duyvenvoorde, H.A., van Haeringen, A., Werner, F., Boudin, E., Schmidt, H., Mueller, T.D., Kuhn, M., and van der Kaay, D.C.M. (2020) An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature, J Clin Endocrinol Metab, 105(7), available:
  • Schinner, C., Erber, B.M., Yeruva, S., Schlipp, A., Rötzer, V., Kempf, E., Kant, S., Leube, R.E., Mueller, T.D., and Waschke, J. (2020) Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy, {JCI} Insight, 5(9), available:
  • Malinauskas, T., Peer, T.V., Bishop, B., Mueller, T.D., and Siebold, C. (2020) Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, available:
2019[ to top ]
  • Keller, T., Gorboulev, V., Mueller, T.D., D{ö}tsch, V., Bernhard, F., and Koepsell, H. (2019) Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer, Mol Pharmacol, 95(2), 169–182, available:
  • Nickel, J. and Mueller, T.D. (2019) Specification of BMP Signaling, Cells, 8(12), available:
  • Scheide-Noeth, J.P., Rosen, M., Baumstark, D., Dietz, H., and Mueller, T.D. (2019) Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121, J Mol Biol, 431(4), 714–731, available:
  • Vissing, J., Johnson, K., T{ö}pf, A., Nafissi, S., D{í}az-Manera, J., French, V.M., Schindler, R.F., Sarathchandra, P., Lokken, N., Rinn{é}, S., Freund, M., Decher, N., M{ü}ller, T., Duno, M., Krag, T., Brand, T., and Straub, V. (2019) POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy, Ann Neurol, 86(6), 832–843, available:
2018[ to top ]
  • Bertho, S., Herpin, A., Branthonne, A., Jouanno, E., Yano, A., Nicol, B., Muller, T., Pannetier, M., Pailhoux, E., Miwa, M., Yoshizaki, G., Schartl, M., and Guiguen, Y. (2018) The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway, Proc Natl Acad Sci U S A, available:
  • Braun, A.C., Gutmann, M., Mueller, T.D., L{ü}hmann, T., and Meinel, L. (2018) Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate, J Control Release, 279, 17–28, available:
  • Hedrich, R., Mueller, T.D., Becker, D., and Marten, I. (2018) Structure and Function of TPC1 Vacuole SV Channel Gains Shape, Mol Plant, available:
  • Siverino, C., Tabisz, B., L{ü}hmann, T., Meinel, L., M{ü}ller, T., Walles, H., and Nickel, J. (2018) Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry, J Vis Exp, (133), available:
  • Mumcuoglu, D., de Miguel, L., Jekhmane, S., Siverino, C., Nickel, J., Mueller, T.D., van Leeuwen, J.P., van Osch, G.J., and Kluijtmans, S.G. (2018) Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2, Mater Sci Eng C Mater Biol Appl, 84, 271–280, available:
  • Gorboulev, V., Rehman, S., Albert, C.M., Roth, U., Meyer, M.J., Tzvetkov, M.V., Mueller, T.D., and Koepsell, H. (2018) Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake, Mol Pharmacol, available:
  • Nickel, J., Ten Dijke, P., and Mueller, T.D. (2018) TGF-β family co-receptor function and signaling, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, available:
2017[ to top ]
  • Lagler, C., El-Mesery, M., K{ü}bler, A.C., M{ü}ller-Richter, U.D.A., St{ü}hmer, T., Nickel, J., M{ü}ller, T.D., Wajant, H., and Seher, A. (2017) The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent, PLoS One, 12(10), available:
  • Patino, L., Walton, K.L., Mueller, T., Johnson, K.E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R.B., Laissue, P., and Harrison, C.A. (2017) BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9, J Clin Endocrinol Metab, 102(3), 1009–1019.
  • Silva-Vilches, C., Pletinckx, K., Lohnert, M., Pavlovic, V., Ashour, D., John, V., Vendelova, E., Kneitz, S., Zhou, J., Chen, R., Reinheckel, T., Mueller, T.D., Bodem, J., and Lutz, M.B. (2017) Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion, PLoS One, 12(7), available:
  • Jodeleit, H., Palamides, P., Beigel, F., Mueller, T., Wolf, E., Siebeck, M., and Gropp, R. (2017) Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model, J Transl Med, 15(1), 265–265, available:
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J.C., Meinel, L., Fiebig, J.E., Mueller, T.D., and Nickel, J. (2017) Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds, Biomacromolecules, 18(3), 695–708, available:
  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U.D.A., Kübler, A.C., Sebald, W., Müller, T.D., and Nickel, J. (2017) Utilizing BMP-2 muteins for treatment of multiple myeloma, PLOS ONE, 12(5), 1–18, available:
  • Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., M{ü}ller, T.D., and Piehler, J. (2017) Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments, Nat Commun, 8, 15976–15976, available:
  • Lenglet, A., Jaślan, D., Toyota, M., Mueller, M., M{ü}ller, T., Sch{ö}nknecht, G., Marten, I., Gilroy, S., Hedrich, R., and Farmer, E.E. (2017) Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity, New Phytol, 216(4), 1161–1169, available:
2016[ to top ]
  • Jaslan, D., Mueller, T.D., Becker, D., Schultz, J., Cuin, T.A., Marten, I., Dreyer, I., Schonknecht, G., and Hedrich, R. (2016) Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain, Plant Biol (Stuttg), 18(5), 750–60, available:
  • Hinck, A.P., Mueller, T.D., and Springer, T.A. (2016) Structural Biology and Evolution of the TGF-beta Family, Cold Spring Harb Perspect Biol, 8(12), available:
  • Boschert, V., Frisch, C., Back, J.W., van Pee, K., Weidauer, S.E., Muth, E.M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., and Mueller, T.D. (2016) The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6, Open Biol, 6(8), available:
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T.D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K.A., Rennenberg, H., Shabala, S., Neher, E., and Hedrich, R. (2016) The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake, Curr Biol, 26(3), 286–95, available:
  • Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinne, S., Froese, A., Nikolaev, V.O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., and Ferlini, A. (2016) POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking, J Clin Invest, 126(1), 239–53, available:
  • Chintalapati, C., Keller, T., Mueller, T.D., Gorboulev, V., Schafer, N., Zilkowski, I., Veyhl-Wichmann, M., Geiger, D., Groll, J., and Koepsell, H. (2016) Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase, Mol Pharmacol, 90(5), 508–521, available:
  • Palamides, P., Jodeleit, H., Fohlinger, M., Beigel, F., Herbach, N., Mueller, T., Wolf, E., Siebeck, M., and Gropp, R. (2016) A mouse model for ulcerative colitis based on NOD-scid IL2R gammanull mice reconstituted with peripheral blood mononuclear cells from affected individuals, Dis Model Mech, 9(9), 985–97, available:
  • Yadin, D., Knaus, P., and Mueller, T.D. (2016) Structural insights into BMP receptors: Specificity, activation and inhibition, Cytokine Growth Factor Rev, 27, 13–34, available:
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A.L., Bauerlein, C.A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K.J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T.D., Reddehase, M.J., Lutz, M.B., Mannel, D.N., Berberich-Siebelt, F., Wajant, H., and Beilhack, A. (2016) Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion, J Exp Med, 213(9), 1881–900, available:
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M.G., Fiebig, J., Mueller, T.D., and Meinel, L. (2016) Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization, Chembiochem, 17(22), 2123–2128, available:
  • Deeken, R., Saupe, S., Klinkenberg, J., Riedel, M., Leide, J., Hedrich, R., and Mueller, T.D. (2016) The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls, Plant Physiol, 172(3), 1911–1927, available:
  • Johnson, K.E., Makanji, Y., Temple-Smith, P., Kelly, E.K., Barton, P.A., Al-Musawi, S.L., Mueller, T.D., Walton, K.L., and Harrison, C.A. (2016) Biological activity and in vivo half-life of pro-activin A in male rats, Mol Cell Endocrinol, 422, 84–92, available:
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., and Hedrich, R. (2016) Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, 9(3), 428–36, available:
  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A.R., Ehrlich, M., Henis, Y.I., Muller, T., and Knaus, P. (2016) Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling, Int J Biochem Cell Biol, 76, 51–63, available:
  • Vendelova, E., Camargo de Lima, J., Lorenzatto, K.R., Monteiro, K.M., Mueller, T., Veepaschit, J., Grimm, C., Brehm, K., Hrckova, G., Lutz, M.B., Ferreira, H.B., and Nono, J.K. (2016) Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions, PLoS Negl Trop Dis, 10(10), e0005061, available:
2015[ to top ]
  • Mueller, T.D. (2015) Mechanisms of BMP-Receptor Interaction and Activation, Vitam Horm, 99, 1–61, available:
  • Mueller, T.D. (2015) RGM co-receptors add complexity to BMP signaling, Nat Struct Mol Biol, 22(6), 439–40, available:
  • Paletta, D., Fichtner, A.S., Hahn, A.M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T.D., and Herrmann, T. (2015) The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs, Eur J Immunol, 45(7), 2122–33, available:
  • Li, J.J., Sugimura, S., Mueller, T.D., White, M.A., Martin, G.A., Ritter, L.J., Liang, X.Y., Gilchrist, R.B., and Mottershead, D.G. (2015) Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes, Mol Endocrinol, 29(1), 40–52, available:
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., and Hedrich, R. (2015) Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, available:
  • Mottershead, D.G., Sugimura, S., Al-Musawi, S.L., Li, J.J., Richani, D., White, M.A., Martin, G.A., Trotta, A.P., Ritter, L.J., Shi, J., Mueller, T.D., Harrison, C.A., and Gilchrist, R.B. (2015) Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-beta Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality, J Biol Chem, 290(39), 24007–20, available:
  • Klammert, U., Mueller, T.D., Hellmann, T.V., Wuerzler, K.K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A.C., Sebald, W., and Nickel, J. (2015) GDF-5 can act as a context-dependent BMP-2 antagonist, BMC Biol, 13, 77, available:
  • Boschert, V., Muth, E.M., Knappik, A., Frisch, C., and Mueller, T.D. (2015) Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, available:
  • Stange, K., Desir, J., Kakar, N., Mueller, T.D., Budde, B.S., Gordon, C.T., Horn, D., Seemann, P., and Borck, G. (2015) A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia, Orphanet J Rare Dis, 10, 84, available:
2014[ to top ]
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K.A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T.D., and Geiger, D. (2014) A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective, Plant Cell, 26(6), 2554–2567, available:
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Hermanns, H.M., Schafer, C.M., Kottmair, M., Muller, T., and Sebald, W. (2014) IL-4 analogues with site-specific chemical modification at position 121 inhibit IL-4 and IL-13 biological activities, Bioconjugate chemistry, 25(1), 52–62, available:
  • Tzvetkov, M.V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., and Koepsell, H. (2014) Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?, Blood, 123(9), 1427–9, available:
  • Graul-Neumann, L.M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T.D., Doelken, S.C., and Seemann, P. (2014) Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe, European journal of human genetics : EJHG, 22(6), 726–33, available:
2013[ to top ]
  • Fiebig, J.E., Weidauer, S.E., Qiu, L.Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.L., Oschkinat, H., Sebald, W., and Mueller, T.D. (2013) The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed, Molecules, 18(10), 11658–82, available:
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T.V., Mueller, T.D., Nickel, J., Eichler, J., and Muller, Y.A. (2013) Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3), PLoS One, 8(6), e67214, available:
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Varga, R., Herbach, N., Wanke, R., Wollenberg, A., Mueller, T., Gropp, R., Wolf, E., and Siebeck, M. (2013) Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells, Disease models & mechanisms, 6(1), 125–34, available:
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., and Gropp, R. (2013) Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells, Clinical and experimental immunology, 172(2), 349–62, available:
  • Laisney, J.A., Mueller, T.D., Schartl, M., and Meierjohann, S. (2013) Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops, Oncogene, 32(19), 2403–11, available:
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E.M., Ten Dijke, P., and Mueller, T.D. (2013) Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition, PLoS One, 8(11), e81710, available:
  • Mottershead, D.G., Harrison, C.A., Mueller, T.D., Stanton, P.G., Gilchrist, R.B., and McNatty, K.P. (2013) Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available:
  • van Dinther, M., Zhang, J., Weidauer, S.E., Boschert, V., Muth, E.M., Knappik, A., de Gorter, D.J., van Kasteren, P.B., Frisch, C., Mueller, T.D., and Ten Dijke, P. (2013) Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling, PLoS One, 8(4), e62295, available:
  • Zadeh-Khorasani, M., Nolte, T., Mueller, T.D., Pechlivanis, M., Rueff, F., Wollenberg, A., Fricker, G., Wolf, E., Siebeck, M., and Gropp, R. (2013) NOD-scid IL2R gammanull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways, Journal of translational medicine, 11, 4, available:
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R.P., Rapp, U.R., Rudel, T., and Baljuls, A. (2013) Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase, The Journal of biological chemistry, 288(49), 35237–52, available:
  • Hannema, S.E., van Duyvenvoorde, H.A., Premsler, T., Yang, R.B., Mueller, T.D., Gassner, B., Oberwinkler, H., Roelfsema, F., Santen, G.W., Prickett, T., Kant, S.G., Verkerk, A.J., Uitterlinden, A.G., Espiner, E., Ruivenkamp, C.A., Oostdijk, W., Pereira, A.M., Losekoot, M., Kuhn, M., and Wit, J.M. (2013) An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities, The Journal of clinical endocrinology and metabolism, 98(12), E1988–98, available:
  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K.A., Neher, E., and Hedrich, R. (2013) The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion, Current biology : CB, 23(17), 1649–57, available:
  • Whitman, M., Rosen, V., Brivanlou, A.H., Groppe, J.C., Sebald, W., and Mueller, T. (2013) Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3, Nature medicine, 19(7), 809–10, available:
2012[ to top ]
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T.D., and Sebald, W. (2012) Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol, Bioconjugate chemistry, 23(7), 1396–405, available:
  • Hellmann, T., Nickel, J., and Mueller, T. (2012) Missense mutations in GDF5 signaling: molecular mechanisms behind skeletal malformation, in Cooper, D. and Chen, J.-M., eds., Gene Mutation, Rijeka, Croatia: InTech.
  • Schwaerzer, G.K., Hiepen, C., Schrewe, H., Nickel, J., Ploeger, F., Sebald, W., Mueller, T., and Knaus, P. (2012) New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance, J Bone Miner Res, 27(2), 429–442, available:
  • Urusova, D.V., Isupov, M.N., Antonyuk, S., Kachalova, G.S., Obmolova, G., Vagin, A.A., Lebedev, A.A., Burenkov, G.P., Dauter, Z., Bartunik, H.D., Lamzin, V.S., Melik-Adamyan, W.R., Mueller, T.D., and Schnackerz, K.D. (2012) Crystal structure of D-serine dehydratase from Escherichia coli, Biochim Biophys Acta, 1824(3), 422–32, available:
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T.D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., and Becker, D. (2012) Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs), Molecular Plant, 6(4), 1274–1289, available:
  • Froese, A., Breher, S.S., Waldeyer, C., Schindler, R.F., Nikolaev, V.O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S.K., Laakmann, S., Muller, T.D., Neumann, J., Stieber, J., Ludwig, A., Maier, S.K., Decher, N., Arnold, H.H., Kirchhof, P., Fabritz, L., and Brand, T. (2012) Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice, J Clin Invest, 122(3), 1119–30, available:
  • Back, J.W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T.D., Knappik, A., and Timmerman, P. (2012) Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin, Protein Eng Des Sel, 25(5), 251–9, available:
  • Mueller, T.D. and Nickel, J. (2012) Promiscuity and specificity in BMP receptor activation, FEBS letters, 586(14), 1846–59, available:
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T.D., and Koepsell, H. (2012) A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1, J Biol Chem, 287(37), 31561–73, available:
2011[ to top ]
  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., and Mueller, T.D. (2011) Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha, Structure, 19(12), 1864–75, available:
  • Nickel, J., Kotzsch, A., Sebald, W., and Mueller, T.D. (2011) Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA), Acta Cryst F, 67(Pt 5), 551–5, available:
  • Dadacz-Narloch, B., Beyhl, D., Larisch, C., Lopez-Sanjurjo, E.J., Reski, R., Kuchitsu, K., Muller, T.D., Becker, D., Schonknecht, G., and Hedrich, R. (2011) A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels, Plant Cell, 23(7), 2696–707, available:
  • Seher, A., Nickel, J., Mueller, T.D., Kneitz, S., Gebhardt, S., ter Vehn, T.M., Schlunck, G., and Sebald, W. (2011) Gene expression profiling of connective tissue growth factor (CTGF) stimulated primary human tenon fibroblasts reveals an inflammatory and wound healing response in vitro, Molecular Vision, 17, 53–62, available:
  • {Billington, C.J., Fiebig, J.E., Forsman, C.L., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O’Connor, M.B., Mueller, T.D., and Petryk, A. (2011) Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development, Front Physiol, 2, 59, available:
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., and Rapp, U.R. (2011) Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase, J Biol Chem, 286(18), 16491–503, available:
2010[ to top ]
  • Marcel, D., Muller, T., Hedrich, R., and Geiger, D. (2010) K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs, FEBS Lett, 584(11), 2433–9, available:
  • Harth, S., Kotzsch, A., Sebald, W., and Mueller, T.D. (2010) Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, available:
  • Harth, S., Kotzsch, A., Hu, J., Sebald, W., and Mueller, T.D. (2010) A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity, PLoS One, 5(9), available:
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J.P., Van Hul, W., and Papapoulos, S. (2010) First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function, Hum Mutat, 31(7), E1526–43, available:
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S.E., de Gorter, D.J., van Bezooijen, R.L., Hatsell, S., Economides, A.N., Mueller, T.D., Lowik, C.W., and ten Dijke, P. (2010) Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways, J Biol Chem, 285(53), 41614–26, available:
  • Sebald, W., Nickel, J., Zhang, J.L., and Mueller, T.D. (2010) Molecular basis of cytokine signalling--theme and variations, FEBS J, 277(1), 106–18, available:
2009[ to top ]
  • Spindler, V., Heupel, W.-M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Müller, T., Drenckhahn, D., and Waschke, J. (2009) Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus, Journal of Biological Chemistry, 284(44), 30556–30564, available:
  • Weidauer, S.E., Schmieder, P., Beerbaum, M., Schmitz, W., Oschkinat, H., and Mueller, T.D. (2009) NMR structure of the Wnt modulator protein Sclerostin, Biochem Biophys Res Commun, 380(1), 160–5, available:
  • Schmitt, B.M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., and Koepsell, H. (2009) Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine, Am J Physiol Renal Physiol, 296(4), F709–22, available:
  • Heupel, W.M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., and Waschke, J. (2009) Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus, J Biol Chem, 284(13), 8589–95, available:
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T.D., Srinivasan, A., Hubner, S., and Koepsell, H. (2009) Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location, Traffic, 10(11), 1599–618, available: