Department of Botany I - Plant-Physiology and Biophysics


Publication List Prof. Thomas Müller

2021[ to top ]
  • Imarazene, B., Du, K., Beille, S., Jouanno, E., Feron, R., Pan, Q., Torres-Paz, J., Lopez-Roques, C., Castinel, A., Gil, L., Kuchly, C., Donnadieu, C., Parrinello, H., Journot, L., Cabau, C., Zahm, M., Klopp, C., Pavlica, T., Al-Rikabi, A., Liehr, T., Simanovsky, S.A., Bohlen, J., Sember, A., Perez, J., Veyrunes, F., Mueller, T.D., Postlethwait, J.H., Schartl, M., Herpin, A., Rétaux, S., Guiguen, Y. (2021) A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus, Current Biology, 31(21), 4800–4809.e9, available: https://www.sciencedirect.com/science/article/pii/S0960982221011349.
  • Lehmann, J., Jørgensen, M.E., Fratz, S., Müller, H.M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K.R., Terpitz, U., Dreyer, I., Mueller, T.D., Sauer, M., Hedrich, R., Geiger, D., Maierhofer, T. (2021) Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis, Current Biology, available: https://www.sciencedirect.com/science/article/pii/S0960982221008137.
  • Heinks, T., Hettwer, A., Hiepen, C., Weise, C., Gorka, M., Knaus, P., Mueller, T.D., Loidl-Stahlhofen, A. (2021) Optimized expression and purification of a soluble BMP2 variant based on in-silico design, Protein Expression and Purification, 186, 105918, available: https://www.sciencedirect.com/science/article/pii/S1046592821001017.
2020[ to top ]
  • Malinauskas, T., Peer, T.V., Bishop, B., Mueller, T.D., Siebold, C. (2020) Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, available: https://www.pnas.org/content/117/27/15620.
  • Schinner, C., Erber, B.M., Yeruva, S., Schlipp, A., Rötzer, V., Kempf, E., Kant, S., Leube, R.E., Mueller, T.D., Waschke, J. (2020) Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy, {JCI} Insight, 5(9), available: https://doi.org/10.1172%2Fjci.insight.130141.
  • Lauffer, P., Miranda-Laferte, E., van Duyvenvoorde, H.A., van Haeringen, A., Werner, F., Boudin, E., Schmidt, H., Mueller, T.D., Kuhn, M., van der Kaay, D.C.M. (2020) An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature, J Clin Endocrinol Metab, 105(7), available: https://pubmed.ncbi.nlm.nih.gov/32282051/.
2019[ to top ]
  • Keller, T., Gorboulev, V., Mueller, T.D., D{\"o}tsch, V., Bernhard, F., Koepsell, H. (2019) Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer, Mol Pharmacol, 95(2), 169–182, available: https://www.ncbi.nlm.nih.gov/pubmed/30409791.
  • Scheide-Noeth, J.P., Rosen, M., Baumstark, D., Dietz, H., Mueller, T.D. (2019) Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121, J Mol Biol, 431(4), 714–731, available: https://www.ncbi.nlm.nih.gov/pubmed/30529748.
  • Vissing, J., Johnson, K., T{\"o}pf, A., Nafissi, S., D{\’i}az-Manera, J., French, V.M., Schindler, R.F., Sarathchandra, P., Lokken, N., Rinn{\’e}, S., Freund, M., Decher, N., M{\"u}ller, T., Duno, M., Krag, T., Brand, T., Straub, V. (2019) POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy, Ann Neurol, 86(6), 832–843, available: https://www.ncbi.nlm.nih.gov/pubmed/31610034.
  • Nickel, J., Mueller, T.D. (2019) Specification of BMP Signaling, Cells, 8(12), available: https://www.ncbi.nlm.nih.gov/pubmed/31817503.
2018[ to top ]
  • Bertho, S., Herpin, A., Branthonne, A., Jouanno, E., Yano, A., Nicol, B., Muller, T., Pannetier, M., Pailhoux, E., Miwa, M., Yoshizaki, G., Schartl, M., Guiguen, Y. (2018) The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway, Proc Natl Acad Sci U S A, available: https://www.ncbi.nlm.nih.gov/pubmed/30463951.
  • Siverino, C., Tabisz, B., L{\"u}hmann, T., Meinel, L., M{\"u}ller, T., Walles, H., Nickel, J. (2018) Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry, J Vis Exp, (133), available: https://www.ncbi.nlm.nih.gov/pubmed/29658921.
  • Braun, A.C., Gutmann, M., Mueller, T.D., L{\"u}hmann, T., Meinel, L. (2018) Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate, J Control Release, 279, 17–28, available: https://www.ncbi.nlm.nih.gov/pubmed/29634992.
  • Hedrich, R., Mueller, T.D., Becker, D., Marten, I. (2018) Structure and Function of TPC1 Vacuole SV Channel Gains Shape, Mol Plant, available: https://www.ncbi.nlm.nih.gov/pubmed/29614320.
  • Mumcuoglu, D., de Miguel, L., Jekhmane, S., Siverino, C., Nickel, J., Mueller, T.D., van Leeuwen, J.P., van Osch, G.J., Kluijtmans, S.G. (2018) Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2, Mater Sci Eng C Mater Biol Appl, 84, 271–280, available: https://www.ncbi.nlm.nih.gov/pubmed/29519439.
  • Nickel, J., Ten Dijke, P., Mueller, T.D. (2018) TGF-β family co-receptor function and signaling, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, available: https://www.ncbi.nlm.nih.gov/pubmed/29293886.
  • Gorboulev, V., Rehman, S., Albert, C.M., Roth, U., Meyer, M.J., Tzvetkov, M.V., Mueller, T.D., Koepsell, H. (2018) Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake, Mol Pharmacol, available: https://www.ncbi.nlm.nih.gov/pubmed/29339398.
2017[ to top ]
  • Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K.C., M{\"u}ller, T.D., Piehler, J. (2017) Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments, Nat Commun, 8, 15976–15976, available: https://www.ncbi.nlm.nih.gov/pubmed/28706306.
  • Patino, L., Walton, K.L., Mueller, T., Johnson, K.E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R.B., Laissue, P., Harrison, C.A. (2017) BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9, J Clin Endocrinol Metab, 102(3), 1009–1019.
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J.C., Meinel, L., Fiebig, J.E., Mueller, T.D., Nickel, J. (2017) Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds, Biomacromolecules, 18(3), 695–708, available: https://www.ncbi.nlm.nih.gov/pubmed/28211679.
  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U.D.A., Kübler, A.C., Sebald, W., Müller, T.D., Nickel, J. (2017) Utilizing BMP-2 muteins for treatment of multiple myeloma, PLOS ONE, 12(5), 1–18, available: https://doi.org/10.1371/journal.pone.0174884.
  • Jodeleit, H., Palamides, P., Beigel, F., Mueller, T., Wolf, E., Siebeck, M., Gropp, R. (2017) Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model, J Transl Med, 15(1), 265–265, available: https://www.ncbi.nlm.nih.gov/pubmed/29282132.
  • Silva-Vilches, C., Pletinckx, K., Lohnert, M., Pavlovic, V., Ashour, D., John, V., Vendelova, E., Kneitz, S., Zhou, J., Chen, R., Reinheckel, T., Mueller, T.D., Bodem, J., Lutz, M.B. (2017) Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion, PLoS One, 12(7), available: https://www.ncbi.nlm.nih.gov/pubmed/28759565.
  • Lagler, C., El-Mesery, M., K{\"u}bler, A.C., M{\"u}ller-Richter, U.D.A., St{\"u}hmer, T., Nickel, J., M{\"u}ller, T.D., Wajant, H., Seher, A. (2017) The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent, PLoS One, 12(10), available: https://www.ncbi.nlm.nih.gov/pubmed/29028819.
  • Lenglet, A., Jaślan, D., Toyota, M., Mueller, M., M{\"u}ller, T., Sch{\"o}nknecht, G., Marten, I., Gilroy, S., Hedrich, R., Farmer, E.E. (2017) Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity, New Phytol, 216(4), 1161–1169, available: https://www.ncbi.nlm.nih.gov/pubmed/28885692.
2016[ to top ]
  • Yadin, D., Knaus, P., Mueller, T.D. (2016) Structural insights into BMP receptors: Specificity, activation and inhibition, Cytokine Growth Factor Rev, 27, 13–34, available: https://www.ncbi.nlm.nih.gov/pubmed/26690041.
  • Boschert, V., Frisch, C., Back, J.W., van Pee, K., Weidauer, S.E., Muth, E.M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., Mueller, T.D. (2016) The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6, Open Biol, 6(8), available: https://www.ncbi.nlm.nih.gov/pubmed/27558933.
  • Hinck, A.P., Mueller, T.D., Springer, T.A. (2016) Structural Biology and Evolution of the TGF-beta Family, Cold Spring Harb Perspect Biol, 8(12), available: https://www.ncbi.nlm.nih.gov/pubmed/27638177.
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A.L., Bauerlein, C.A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K.J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T.D., Reddehase, M.J., Lutz, M.B., Mannel, D.N., Berberich-Siebelt, F., Wajant, H., Beilhack, A. (2016) Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion, J Exp Med, 213(9), 1881–900, available: https://www.ncbi.nlm.nih.gov/pubmed/27526711.
  • Schindler, R.F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K.L., Fang, M., Rinne, S., Froese, A., Nikolaev, V.O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F.R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., Ferlini, A. (2016) POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking, J Clin Invest, 126(1), 239–53, available: https://www.ncbi.nlm.nih.gov/pubmed/26642364.
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T.D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K.A., Rennenberg, H., Shabala, S., Neher, E., Hedrich, R. (2016) The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake, Curr Biol, 26(3), 286–95, available: https://www.ncbi.nlm.nih.gov/pubmed/26804557.
  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A.R., Ehrlich, M., Henis, Y.I., Muller, T., Knaus, P. (2016) Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling, Int J Biochem Cell Biol, 76, 51–63, available: https://www.ncbi.nlm.nih.gov/pubmed/27113717.
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M.G., Fiebig, J., Mueller, T.D., Meinel, L. (2016) Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization, Chembiochem, 17(22), 2123–2128, available: https://www.ncbi.nlm.nih.gov/pubmed/27595549.
2015[ to top ]
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T.D., Hedrich, R. (2015) Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, available: http://www.ncbi.nlm.nih.gov/pubmed/26455461.
  • Mueller, T.D. (2015) Mechanisms of BMP-Receptor Interaction and Activation, Vitam Horm, 99, 1–61, available: http://www.ncbi.nlm.nih.gov/pubmed/26279372.
  • Mueller, T.D. (2015) RGM co-receptors add complexity to BMP signaling, Nat Struct Mol Biol, 22(6), 439–40, available: http://www.ncbi.nlm.nih.gov/pubmed/26036568.
  • Boschert, V., Muth, E.M., Knappik, A., Frisch, C., Mueller, T.D. (2015) Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, available: http://www.ncbi.nlm.nih.gov/pubmed/25849496.
  • Paletta, D., Fichtner, A.S., Hahn, A.M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T.D., Herrmann, T. (2015) The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs, Eur J Immunol, 45(7), 2122–33, available: http://www.ncbi.nlm.nih.gov/pubmed/25900449.
  • Stange, K., Desir, J., Kakar, N., Mueller, T.D., Budde, B.S., Gordon, C.T., Horn, D., Seemann, P., Borck, G. (2015) A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia, Orphanet J Rare Dis, 10, 84, available: http://www.ncbi.nlm.nih.gov/pubmed/26105076.
  • Klammert, U., Mueller, T.D., Hellmann, T.V., Wuerzler, K.K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A.C., Sebald, W., Nickel, J. (2015) GDF-5 can act as a context-dependent BMP-2 antagonist, BMC Biol, 13, 77, available: http://www.ncbi.nlm.nih.gov/pubmed/26385096.
2014[ to top ]
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K.A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T.D., Geiger, D. (2014) A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective, Plant Cell, 26(6), 2554–2567, available: http://www.ncbi.nlm.nih.gov/pubmed/24938289.
  • Tzvetkov, M.V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., Koepsell, H. (2014) Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?, Blood, 123(9), 1427–9, available: http://www.ncbi.nlm.nih.gov/pubmed/24578499.
  • Graul-Neumann, L.M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T.D., Doelken, S.C., Seemann, P. (2014) Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe, European journal of human genetics : EJHG, 22(6), 726–33, available: http://www.ncbi.nlm.nih.gov/pubmed/24129431.
2013[ to top ]
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., Gropp, R. (2013) Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells, Clinical and experimental immunology, 172(2), 349–62, available: http://www.ncbi.nlm.nih.gov/pubmed/23574330.
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R.P., Rapp, U.R., Rudel, T., Baljuls, A. (2013) Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase, The Journal of biological chemistry, 288(49), 35237–52, available: http://www.ncbi.nlm.nih.gov/pubmed/24158441.
  • Fiebig, J.E., Weidauer, S.E., Qiu, L.Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.L., Oschkinat, H., Sebald, W., Mueller, T.D. (2013) The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed, Molecules, 18(10), 11658–82, available: http://www.ncbi.nlm.nih.gov/pubmed/24071977.
  • Mottershead, D.G., Harrison, C.A., Mueller, T.D., Stanton, P.G., Gilchrist, R.B., McNatty, K.P. (2013) Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available: http://www.ncbi.nlm.nih.gov/pubmed/23650403.
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E.M., Ten Dijke, P., Mueller, T.D. (2013) Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition, PLoS One, 8(11), e81710, available: http://www.ncbi.nlm.nih.gov/pubmed/24312339.
  • van Dinther, M., Zhang, J., Weidauer, S.E., Boschert, V., Muth, E.M., Knappik, A., de Gorter, D.J., van Kasteren, P.B., Frisch, C., Mueller, T.D., Ten Dijke, P. (2013) Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling, PLoS One, 8(4), e62295, available: http://www.ncbi.nlm.nih.gov/pubmed/23638027.
  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K.A., Neher, E., Hedrich, R. (2013) The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion, Current biology : CB, 23(17), 1649–57, available: http://www.ncbi.nlm.nih.gov/pubmed/23954430.
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T.V., Mueller, T.D., Nickel, J., Eichler, J., Muller, Y.A. (2013) Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3), PLoS One, 8(6), e67214, available: http://www.ncbi.nlm.nih.gov/pubmed/23826237.
  • Laisney, J.A., Mueller, T.D., Schartl, M., Meierjohann, S. (2013) Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops, Oncogene, 32(19), 2403–11, available: http://www.ncbi.nlm.nih.gov/pubmed/22751127.
2012[ to top ]
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T.D., Koepsell, H. (2012) A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1, J Biol Chem, 287(37), 31561–73, available: http://www.ncbi.nlm.nih.gov/pubmed/22810231.
  • Froese, A., Breher, S.S., Waldeyer, C., Schindler, R.F., Nikolaev, V.O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S.K., Laakmann, S., Muller, T.D., Neumann, J., Stieber, J., Ludwig, A., Maier, S.K., Decher, N., Arnold, H.H., Kirchhof, P., Fabritz, L., Brand, T. (2012) Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice, J Clin Invest, 122(3), 1119–30, available: http://www.ncbi.nlm.nih.gov/pubmed/22354168.
  • Urusova, D.V., Isupov, M.N., Antonyuk, S., Kachalova, G.S., Obmolova, G., Vagin, A.A., Lebedev, A.A., Burenkov, G.P., Dauter, Z., Bartunik, H.D., Lamzin, V.S., Melik-Adamyan, W.R., Mueller, T.D., Schnackerz, K.D. (2012) Crystal structure of D-serine dehydratase from Escherichia coli, Biochim Biophys Acta, 1824(3), 422–32, available: http://www.ncbi.nlm.nih.gov/pubmed/22197591.
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T.D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., Becker, D. (2012) Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs), Molecular Plant, 6(4), 1274–1289, available: http://www.ncbi.nlm.nih.gov/pubmed/23253603.
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T.D., Sebald, W. (2012) Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol, Bioconjugate chemistry, 23(7), 1396–405, available: http://www.ncbi.nlm.nih.gov/pubmed/22681442.
  • Back, J.W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T.D., Knappik, A., Timmerman, P. (2012) Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin, Protein Eng Des Sel, 25(5), 251–9, available: http://www.ncbi.nlm.nih.gov/pubmed/22454505.
2011[ to top ]
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., Rapp, U.R. (2011) Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase, J Biol Chem, 286(18), 16491–503, available: http://www.ncbi.nlm.nih.gov/pubmed/21454547.
  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., Mueller, T.D. (2011) Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha, Structure, 19(12), 1864–75, available: http://www.ncbi.nlm.nih.gov/pubmed/22153509.
2010[ to top ]
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S.E., de Gorter, D.J., van Bezooijen, R.L., Hatsell, S., Economides, A.N., Mueller, T.D., Lowik, C.W., ten Dijke, P. (2010) Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways, J Biol Chem, 285(53), 41614–26, available: http://www.ncbi.nlm.nih.gov/pubmed/20952383.
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J.P., Van Hul, W., Papapoulos, S. (2010) First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function, Hum Mutat, 31(7), E1526–43, available: http://www.ncbi.nlm.nih.gov/pubmed/20583295.
  • Harth, S., Kotzsch, A., Sebald, W., Mueller, T.D. (2010) Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, available: http://www.ncbi.nlm.nih.gov/pubmed/20693682.
  • Sebald, W., Nickel, J., Zhang, J.L., Mueller, T.D. (2010) Molecular basis of cytokine signalling--theme and variations, FEBS J, 277(1), 106–18, available: http://www.ncbi.nlm.nih.gov/pubmed/19951357.
  • Marcel, D., Muller, T., Hedrich, R., Geiger, D. (2010) K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs, FEBS Lett, 584(11), 2433–9, available: http://www.ncbi.nlm.nih.gov/pubmed/20412800.
2009[ to top ]
  • Volk, C., Gorboulev, V., Kotzsch, A., Muller, T.D., Koepsell, H. (2009) Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone, Mol Pharmacol, 76(2), 275–89, available: http://www.ncbi.nlm.nih.gov/pubmed/19435783.
  • Kotzsch, A., Nickel, J., Sebald, W., Mueller, T.D. (2009) Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB), Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779–83, available: http://www.ncbi.nlm.nih.gov/pubmed/19652338.
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T.D., Srinivasan, A., Hubner, S., Koepsell, H. (2009) Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location, Traffic, 10(11), 1599–618, available: http://www.ncbi.nlm.nih.gov/pubmed/19765263.
  • Heupel, W.M., Efthymiadis, A., Schlegel, N., Muller, T., Baumer, Y., Baumgartner, W., Drenckhahn, D., Waschke, J. (2009) Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo, J Cell Sci, 122(Pt 10), 1616–25, available: http://www.ncbi.nlm.nih.gov/pubmed/19420236.
  • Spindler, V., Heupel, W.M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Muller, T., Drenckhahn, D., Waschke, J. (2009) Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus, J Biol Chem, 284(44), 30556–64, available: http://www.ncbi.nlm.nih.gov/pubmed/19717567.
  • Heinecke, K., Seher, A., Schmitz, W., Mueller, T.D., Sebald, W., Nickel, J. (2009) Receptor oligomerization and beyond: a case study in bone morphogenetic proteins, BMC Biol, 7, 59, available: http://www.ncbi.nlm.nih.gov/pubmed/19735544.
  • Schmitt, B.M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., Koepsell, H. (2009) Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine, Am J Physiol Renal Physiol, 296(4), F709–22, available: http://www.ncbi.nlm.nih.gov/pubmed/19211691.
  • Heupel, W.M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., Waschke, J. (2009) Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus, J Biol Chem, 284(13), 8589–95, available: http://www.ncbi.nlm.nih.gov/pubmed/19164289.
  • Kotzsch, A., Nickel, J., Seher, A., Sebald, W., Muller, T.D. (2009) Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity, EMBO J, 28(7), 937–47, available: http://www.ncbi.nlm.nih.gov/pubmed/19229295.
  • Spindler, V., Heupel, W.-M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Müller, T., Drenckhahn, D., Waschke, J. (2009) Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus, Journal of Biological Chemistry, 284(44), 30556–30564, available: https://doi.org/10.1074%2Fjbc.m109.024810.
2008[ to top ]
  • Zhang, J.L., Qiu, L.Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., Mueller, T.D. (2008) Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding, Dev Cell, 14(5), 739–50, available: http://www.ncbi.nlm.nih.gov/pubmed/18477456.
  • Qiu, L.Y., Zhang, J.L., Kotzsch, A., Sebald, W., Mueller, T.D. (2008) Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2, Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307–12, available: http://www.ncbi.nlm.nih.gov/pubmed/18391434.
  • Kotzsch, A., Nickel, J., Seher, A., Heinecke, K., van Geersdaele, L., Herrmann, T., Sebald, W., Mueller, T.D. (2008) Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome, J Biol Chem, 283(9), 5876–87, available: http://www.ncbi.nlm.nih.gov/pubmed/18160401.
  • Klages, J., Kotzsch, A., Coles, M., Sebald, W., Nickel, J., Muller, T., Kessler, H. (2008) The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding, Biochemistry, 47(46), 11930–9, available: http://www.ncbi.nlm.nih.gov/pubmed/18937504.
2007[ to top ]
  • Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., Mueller, T.D. (2007) A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor, BMC Struct Biol, 7, 6, available: http://www.ncbi.nlm.nih.gov/pubmed/17295905.
  • Voss, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T.D., Felbor, U. (2007) CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations, Neurogenetics, 8(4), 249–56, available: http://www.ncbi.nlm.nih.gov/pubmed/17657516.
  • Baljuls, A., Mueller, T., Drexler, H.C., Hekman, M., Rapp, U.R. (2007) Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates, J Biol Chem, 282(36), 26575–90, available: http://www.ncbi.nlm.nih.gov/pubmed/17613527.
  • Sebald, W., Nickel, J., Seher, A., Mueller, T. (2007) Bone morphogenetic proteins, in Baeuerlein, E., Epple, M., Behrens, P. and Pompe, W., eds., Handbook of Biomineralization, Wiley-VCH Verlag GmbH Co. KGaA: Weinheim, 19–34.
  • Mueller, T., Sebald, W. (2007) Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren, BIOspektrum, 3, 236–239.
2006[ to top ]
  • Kraich, M., Klein, M., Patino, E., Harrer, H., Nickel, J., Sebald, W., Mueller, T.D. (2006) A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor, BMC Biol, 4, 13, available: http://www.ncbi.nlm.nih.gov/pubmed/16640778.
  • Meierjohann, S., Mueller, T., Schartl, M., Buehner, M. (2006) A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk, Zebrafish, 3(3), 359–69, available: http://www.ncbi.nlm.nih.gov/pubmed/18377216.
2005[ to top ]
  • Nickel, J., Kotzsch, A., Sebald, W., Mueller, T.D. (2005) A single residue of GDF-5 defines binding specificity to BMP receptor IB, J Mol Biol, 349(5), 933–47, available: http://www.ncbi.nlm.nih.gov/pubmed/15890363.
  • Stahl, S., Gaetzner, S., Mueller, T.D., Felbor, U. (2005) Endostatin phenylalanines 31 and 34 define a receptor binding site, Genes Cells, 10(9), 929–39, available: http://www.ncbi.nlm.nih.gov/pubmed/16115201.
2004[ to top ]
  • Johansson, C., Finger, L.D., Trantirek, L., Mueller, T.D., Kim, S., Laird-Offringa, I.A., Feigon, J. (2004) Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target, J Mol Biol, 337(4), 799–816, available: http://www.ncbi.nlm.nih.gov/pubmed/15033352.
2003[ to top ]
  • Sebald, W., Mueller, T.D. (2003) The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly, Trends Biochem Sci, 28(10), 518–21, available: http://www.ncbi.nlm.nih.gov/pubmed/14559178.
  • Mueller, T.D., Feigon, J. (2003) Structural determinants for the binding of ubiquitin-like domains to the proteasome, EMBO J, 22(18), 4634–45, available: http://www.ncbi.nlm.nih.gov/pubmed/12970176.
2002[ to top ]
  • Mueller, T.D., Feigon, J. (2002) Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions, J Mol Biol, 319(5), 1243–55, available: http://www.ncbi.nlm.nih.gov/pubmed/12079361.
  • Mueller, T.D., Zhang, J.L., Sebald, W., Duschl, A. (2002) Structure, binding, and antagonists in the IL-4/IL-13 receptor system, Biochim Biophys Acta, 1592(3), 237–50, available: http://www.ncbi.nlm.nih.gov/pubmed/12421669.
2000[ to top ]
  • Withers-Ward, E.S., Mueller, T.D., Chen, I.S., Feigon, J. (2000) Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr, Biochemistry, 39(46), 14103–12, available: http://www.ncbi.nlm.nih.gov/pubmed/11087358.
1997[ to top ]
  • Shaw, G.L., Muller, T., Campbell, I.D., Mott, H.R., Oschkinat, H., Mitschang, L. (1997) Constant-time HQQC experiment for protein NMR spectroscopy, Journal of Magnetic Resonance, 124(2), 479–483, available: /brokenurl#<Go to ISI>://WOS:A1997WP82100020.
1995[ to top ]
  • Muller, T., Oehlenschlager, F., Buehner, M. (1995) Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models, Journal of Molecular Biology, 247(2), 360–372, available: /brokenurl#<Go to ISI>://WOS:A1995QP61000017.
  • Duschl, A., Muller, T., Sebald, W. (1995) Antagonistic mutant proteins of interleukin-4, Behring Inst Mitt, (96), 87–94, available: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.
1994[ to top ]
  • Muller, T., Dieckmann, T., Sebald, W., Oschkinat, H. (1994) Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy, Journal of Molecular Biology, 237(4), 423–436, available: /brokenurl#<Go to ISI>://WOS:A1994NF55400007.
  • Muller, T., Sebald, W., Oschkinat, H. (1994) Antagonist Design through Forced Electrostatic Mismatch, Nature Structural Biology, 1(10), 674–676, available: /brokenurl#<Go to ISI>://WOS:A1994QN60600006.
1993[ to top ]
  • Kruse, N., Shen, B.J., Arnold, S., Tony, H.P., Muller, T., Sebald, W. (1993) 2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation, Embo Journal, 12(13), 5121–5129, available: /brokenurl#<Go to ISI>://WOS:A1993MM12000024.