Publications
Publication List Prof. Thomas Müller
- [ 2023 ]
- [ 2022 ]
- [ 2021 ]
- [ 2020 ]
- [ 2019 ]
- [ 2018 ]
- [ 2017 ]
- [ 2016 ]
- [ 2015 ]
- [ 2014 ]
- [ 2013 ]
- [ 2012 ]
- [ 2011 ]
- [ 2010 ]
- [ 2009 ]
- [ 2008 ]
- [ 2007 ]
- [ 2006 ]
- [ 2005 ]
- [ 2004 ]
- [ 2003 ]
- [ 2002 ]
- [ 2000 ]
- [ 1997 ]
- [ 1995 ]
- [ 1994 ]
- [ 1993 ]
2023[ to top ]
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Insights into receptor structure and dynamics at the surface of living cells, Nature Communications, 14(1596), 15, available: https://doi.org/doi: 10.1038/s41467-023-37284-4.(2023)
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TPC1 vacuole SV channel gains further shape – voltage priming of calcium-dependent gating, Trends in Plant Science, 28(6), 673–684, available: https://doi.org/https://doi.org/10.1016/j.tplants.2023.01.001.(2023)
2022[ to top ]
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Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 ({BMP}2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo, International Journal of Molecular Sciences, 23(7), 3928, available: https://doi.org/10.3390/ijms23073928.(2022)
2021[ to top ]
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Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis, Current Biology, available: https://doi.org/https://doi.org/10.1016/j.cub.2021.06.018.(2021)
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Optimized expression and purification of a soluble BMP2 variant based on in-silico design, Protein Expression and Purification, 186, 105918, available: https://doi.org/https://doi.org/10.1016/j.pep.2021.105918.(2021)
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A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus, Current Biology, 31(21), 4800–4809.e9, available: https://doi.org/https://doi.org/10.1016/j.cub.2021.08.030.(2021)
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Acidosis-induced activation of anion channel {SLAH}3 in the flooding-related stress response of Arabidopsis, Current Biology, 31(16), 3575–3585.e9, available: https://doi.org/10.1016/j.cub.2021.06.018.(2021)
2020[ to top ]
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Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex, Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620–15631, available: https://doi.org/https://doi.org/10.1073/pnas.2000561117.(2020)
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Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy, {JCI} Insight, 5(9), available: https://doi.org/10.1172/jci.insight.130141.(2020)
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An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature, J Clin Endocrinol Metab, 105(7), available: https://doi.org/10.1210/clinem/dgaa190.(2020)
2019[ to top ]
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Specification of BMP Signaling, Cells, 8(12), available: https://doi.org/10.3390/cells8121579.(2019)
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POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy, Ann Neurol, 86(6), 832–843, available: https://doi.org/10.1002/ana.25620.(2019)
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Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer, Mol Pharmacol, 95(2), 169–182, available: https://doi.org/10.1124/mol.118.113498.(2019)
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Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121, J Mol Biol, 431(4), 714–731, available: https://doi.org/10.1016/j.jmb.2018.11.029.(2019)
2018[ to top ]
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Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2, Mater Sci Eng C Mater Biol Appl, 84, 271–280, available: https://doi.org/10.1016/j.msec.2017.11.031.(2018)
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Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake, Mol Pharmacol, available: https://doi.org/10.1124/mol.117.110767.(2018)
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TGF-β family co-receptor function and signaling, Acta Biochim Biophys Sin (Shanghai), 50(1), 12–36, available: https://doi.org/10.1093/abbs/gmx126.(2018)
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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry, J Vis Exp, (133), available: https://doi.org/10.3791/56616.(2018)
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Structure and Function of TPC1 Vacuole SV Channel Gains Shape, Mol Plant, available: https://doi.org/10.1016/j.molp.2018.03.017.(2018)
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Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate, J Control Release, 279, 17–28, available: https://doi.org/10.1016/j.jconrel.2018.04.009.(2018)
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The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway, Proc Natl Acad Sci U S A, available: https://doi.org/10.1073/pnas.1803826115.(2018)
2017[ to top ]
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Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model, J Transl Med, 15(1), 265–265, available: https://doi.org/10.1186/s12967-017-1368-4.(2017)
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Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity, New Phytol, 216(4), 1161–1169, available: https://doi.org/10.1111/nph.14754.(2017)
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The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent, PLoS One, 12(10), available: https://doi.org/10.1371/journal.pone.0185720.(2017)
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Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion, PLoS One, 12(7), available: https://doi.org/10.1371/journal.pone.0178114.(2017)
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Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments, Nat Commun, 8, 15976–15976, available: https://doi.org/10.1038/ncomms15976.(2017)
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Utilizing BMP-2 muteins for treatment of multiple myeloma, PLOS ONE, 12(5), 1–18, available: https://doi.org/10.1371/journal.pone.0174884.(2017)
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BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9, J Clin Endocrinol Metab, 102(3), 1009–1019.(2017)
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Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds, Biomacromolecules, 18(3), 695–708, available: https://doi.org/10.1021/acs.biomac.6b01407.(2017)
2016[ to top ]
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POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking, J Clin Invest, 126(1), 239–53, available: https://doi.org/10.1172/JCI79562.(2016)
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Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization, Chembiochem, 17(22), 2123–2128, available: https://doi.org/10.1002/cbic.201600480.(2016)
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Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling, Int J Biochem Cell Biol, 76, 51–63, available: https://doi.org/10.1016/j.biocel.2016.04.010.(2016)
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Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion, J Exp Med, 213(9), 1881–900, available: https://doi.org/10.1084/jem.20151563.(2016)
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The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake, Curr Biol, 26(3), 286–95, available: https://doi.org/10.1016/j.cub.2015.11.057.(2016)
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Structural insights into BMP receptors: Specificity, activation and inhibition, Cytokine Growth Factor Rev, 27, 13–34, available: https://doi.org/10.1016/j.cytogfr.2015.11.005.(2016)
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The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6, Open Biol, 6(8), available: https://doi.org/10.1098/rsob.160120.(2016)
2015[ to top ]
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A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia, Orphanet J Rare Dis, 10, 84, available: https://doi.org/10.1186/s13023-015-0299-5.(2015)
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RGM co-receptors add complexity to BMP signaling, Nat Struct Mol Biol, 22(6), 439–40, available: https://doi.org/10.1038/nsmb.3037.(2015)
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Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097, Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388–92, available: https://doi.org/10.1107/S2053230X1500360X.(2015)
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Mechanisms of BMP-Receptor Interaction and Activation, Vitam Horm, 99, 1–61, available: https://doi.org/10.1016/bs.vh.2015.06.003.(2015)
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Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability, Mol Plant, available: https://doi.org/10.1016/j.molp.2015.09.017.(2015)
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GDF-5 can act as a context-dependent BMP-2 antagonist, BMC Biol, 13, 77, available: https://doi.org/10.1186/s12915-015-0183-8.(2015)
2014[ to top ]
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A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective, Plant Cell, 26(6), 2554–2567, available: https://doi.org/10.1105/tpc.114.125849.(2014)
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Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?, Blood, 123(9), 1427–9, available: https://doi.org/10.1182/blood-2013-11-535864.(2014)
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Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe, European journal of human genetics : EJHG, 22(6), 726–33, available: https://doi.org/10.1038/ejhg.2013.222.(2014)
2013[ to top ]
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The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion, Current biology : CB, 23(17), 1649–57, available: https://doi.org/10.1016/j.cub.2013.07.028.(2013)
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The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed, Molecules, 18(10), 11658–82, available: https://doi.org/10.3390/molecules181011658.(2013)
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Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase, The Journal of biological chemistry, 288(49), 35237–52, available: https://doi.org/10.1074/jbc.M113.490235.(2013)
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Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3), PLoS One, 8(6), e67214, available: https://doi.org/10.1371/journal.pone.0067214.(2013)
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Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops, Oncogene, 32(19), 2403–11, available: https://doi.org/10.1038/onc.2012.267.(2013)
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Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization, Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257, available: https://doi.org/10.1073/pnas.1303459110.(2013)
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Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition, PLoS One, 8(11), e81710, available: https://doi.org/10.1371/journal.pone.0081710.(2013)
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Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling, PLoS One, 8(4), e62295, available: https://doi.org/10.1371/journal.pone.0062295.(2013)
2012[ to top ]
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A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1, J Biol Chem, 287(37), 31561–73, available: https://doi.org/10.1074/jbc.M112.388793.(2012)
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Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol, Bioconjugate chemistry, 23(7), 1396–405, available: https://doi.org/10.1021/bc2004389.(2012)
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Crystal structure of D-serine dehydratase from Escherichia coli, Biochim Biophys Acta, 1824(3), 422–32, available: https://doi.org/10.1016/j.bbapap.2011.10.017.(2012)
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Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs), Molecular Plant, 6(4), 1274–1289, available: https://doi.org/10.1093/mp/sss158.(2012)
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Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin, Protein Eng Des Sel, 25(5), 251–9, available: https://doi.org/10.1093/protein/gzs012.(2012)
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Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice, J Clin Invest, 122(3), 1119–30, available: https://doi.org/10.1172/JCI59410.(2012)
2011[ to top ]
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Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha, Structure, 19(12), 1864–75, available: https://doi.org/10.1016/j.str.2011.08.015.(2011)
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Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase, J Biol Chem, 286(18), 16491–503, available: https://doi.org/10.1074/jbc.M110.194167.(2011)
2010[ to top ]
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Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways, J Biol Chem, 285(53), 41614–26, available: https://doi.org/10.1074/jbc.M110.153890.(2010)
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First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function, Hum Mutat, 31(7), E1526–43, available: https://doi.org/10.1002/humu.21274.(2010)
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Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556, Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964–8, available: https://doi.org/10.1107/S1744309110024681.(2010)
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Molecular basis of cytokine signalling--theme and variations, FEBS J, 277(1), 106–18, available: https://doi.org/10.1111/j.1742-4658.2009.07480.x.(2010)
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K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs, FEBS Lett, 584(11), 2433–9, available: https://doi.org/10.1016/j.febslet.2010.04.038.(2010)
2009[ to top ]
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Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity, EMBO J, 28(7), 937–47, available: https://doi.org/10.1038/emboj.2009.37.(2009)
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Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo, J Cell Sci, 122(Pt 10), 1616–25, available: https://doi.org/10.1242/jcs.040212.(2009)
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Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus, Journal of Biological Chemistry, 284(44), 30556–30564, available: https://doi.org/10.1074/jbc.m109.024810.(2009)
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Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB), Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779–83, available: https://doi.org/10.1107/S1744309109024142.(2009)
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Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone, Mol Pharmacol, 76(2), 275–89, available: https://doi.org/10.1124/mol.109.054783.(2009)
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Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine, Am J Physiol Renal Physiol, 296(4), F709–22, available: https://doi.org/10.1152/ajprenal.90323.2008.(2009)
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Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location, Traffic, 10(11), 1599–618, available: https://doi.org/10.1111/j.1600-0854.2009.00982.x.(2009)
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Receptor oligomerization and beyond: a case study in bone morphogenetic proteins, BMC Biol, 7, 59, available: https://doi.org/10.1186/1741-7007-7-59.(2009)
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Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus, J Biol Chem, 284(44), 30556–64, available: https://doi.org/10.1074/jbc.M109.024810.(2009)
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Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus, J Biol Chem, 284(13), 8589–95, available: https://doi.org/10.1074/jbc.M808813200.(2009)
2008[ to top ]
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The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding, Biochemistry, 47(46), 11930–9, available: https://doi.org/10.1021/bi801059j.(2008)
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Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding, Dev Cell, 14(5), 739–50, available: https://doi.org/10.1016/j.devcel.2008.02.017.(2008)
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Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome, J Biol Chem, 283(9), 5876–87, available: https://doi.org/10.1074/jbc.M706029200.(2008)
2007[ to top ]
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Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates, J Biol Chem, 282(36), 26575–90, available: https://doi.org/10.1074/jbc.M702429200.(2007)
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A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor, BMC Struct Biol, 7, 6, available: https://doi.org/10.1186/1472-6807-7-6.(2007)
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Bone morphogenetic proteins, in Baeuerlein, E., Epple, M., Behrens, P. and Pompe, W., eds., Handbook of Biomineralization, Weinheim: Wiley-VCH Verlag GmbH Co. KGaA, 19–34.(2007)
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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations, Neurogenetics, 8(4), 249–56, available: https://doi.org/10.1007/s10048-007-0098-9.(2007)
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Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren, BIOspektrum, 3, 236–239.(2007)
2006[ to top ]
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A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor, BMC Biol, 4, 13, available: https://doi.org/10.1186/1741-7007-4-13.(2006)
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A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk, Zebrafish, 3(3), 359–69, available: https://doi.org/10.1089/zeb.2006.3.359.(2006)
2005[ to top ]
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Endostatin phenylalanines 31 and 34 define a receptor binding site, Genes Cells, 10(9), 929–39, available: https://doi.org/10.1111/j.1365-2443.2005.00890.x.(2005)
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A single residue of GDF-5 defines binding specificity to BMP receptor IB, J Mol Biol, 349(5), 933–47, available: https://doi.org/10.1016/j.jmb.2005.04.015.(2005)
2004[ to top ]
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Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target, J Mol Biol, 337(4), 799–816, available: https://doi.org/10.1016/j.jmb.2004.01.056.(2004)
2003[ to top ]
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Structural determinants for the binding of ubiquitin-like domains to the proteasome, EMBO J, 22(18), 4634–45, available: https://doi.org/10.1093/emboj/cdg467.(2003)
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The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly, Trends Biochem Sci, 28(10), 518–21, available: https://doi.org/10.1016/j.tibs.2003.08.001.(2003)
2002[ to top ]
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Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions, J Mol Biol, 319(5), 1243–55, available: https://doi.org/10.1016/S0022-2836(02)00302-9.(2002)
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Structure, binding, and antagonists in the IL-4/IL-13 receptor system, Biochim Biophys Acta, 1592(3), 237–50, available: http://www.ncbi.nlm.nih.gov/pubmed/12421669.(2002)
2000[ to top ]
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Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr, Biochemistry, 39(46), 14103–12, available: http://www.ncbi.nlm.nih.gov/pubmed/11087358.(2000)
1997[ to top ]
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Constant-time HQQC experiment for protein NMR spectroscopy, Journal of Magnetic Resonance, 124(2), 479–483, available: https://doi.org/Doi 10.1006/Jmre.1996.1062.(1997)
1995[ to top ]
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Antagonistic mutant proteins of interleukin-4, Behring Inst Mitt, (96), 87–94, available: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356.(1995)
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Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models, Journal of Molecular Biology, 247(2), 360–372, available: https://doi.org/Doi 10.1006/Jmbi.1994.0144.(1995)
1994[ to top ]
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Antagonist Design through Forced Electrostatic Mismatch, Nature Structural Biology, 1(10), 674–676, available: https://doi.org/Doi 10.1038/Nsb1094-674.(1994)
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Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy, Journal of Molecular Biology, 237(4), 423–436, available: https://doi.org/Doi 10.1006/Jmbi.1994.1245.(1994)
1993[ to top ]
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2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation, Embo Journal, 12(13), 5121–5129, available: /brokenurl#<Go to ISI>://WOS:A1993MM12000024.(1993)