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Department of Botany I - Plant-Physiology and Biophysics

Publications

Publication List Prof. Thomas Müller

2021[ to top ]
  • Imarazene, B., Du, K., Beille, S., Jouanno, E., Feron, R., Pan, Q., Torres-Paz, J., Lopez-Roques, C., Castinel, A., Gil, L., Kuchly, C., Donnadieu, C., Parrinello, H., Journot, L., Cabau, C., Zahm, M., Klopp, C., Pavlica, T., Al-Rikabi, A., Liehr, T., Simanovsky, S. A., Bohlen, J., Sember, A., Perez, J., Veyrunes, F., Mueller, T. D., Postlethwait, J. H., Schartl, M., Herpin, A., Rétaux, S., & Guiguen, Y. A supernumerary “B-sex” chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus. Current Biology, 31(21), 4800-4809.e9. https://doi.org/https://doi.org/10.1016/j.cub.2021.08.030
  • Lehmann, J., Jørgensen, M. E., Fratz, S., Müller, H. M., Kusch, J., Scherzer, S., Navarro-Retamal, C., Mayer, D., Böhm, J., Konrad, K. R., Terpitz, U., Dreyer, I., Mueller, T. D., Sauer, M., Hedrich, R., Geiger, D., & Maierhofer, T. Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis. Current Biology. https://doi.org/https://doi.org/10.1016/j.cub.2021.06.018
  • Heinks, T., Hettwer, A., Hiepen, C., Weise, C., Gorka, M., Knaus, P., Mueller, T. D., & Loidl-Stahlhofen, A. Optimized expression and purification of a soluble BMP2 variant based on in-silico design. Protein Expression and Purification, 186, 105918. https://doi.org/https://doi.org/10.1016/j.pep.2021.105918
2020[ to top ]
  • Malinauskas, T., Peer, T. V., Bishop, B., Mueller, T. D., & Siebold, C. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proceedins of the National Academy of Sciences of the United States of America, 117(27), 15620-15631. https://doi.org/https://doi.org/10.1073/pnas.2000561117
  • Schinner, C., Erber, B. M., Yeruva, S., Schlipp, A., Rötzer, V., Kempf, E., Kant, S., Leube, R. E., Mueller, T. D., & Waschke, J. Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. {JCI} Insight, 5(9), Article 9. https://doi.org/10.1172/jci.insight.130141
  • Lauffer, P., Miranda-Laferte, E., van Duyvenvoorde, H. A., van Haeringen, A., Werner, F., Boudin, E., Schmidt, H., Mueller, T. D., Kuhn, M., & van der Kaay, D. C. M. An Activating Deletion Variant in the Submembrane Region of Natriuretic Peptide Receptor-B Causes Tall Stature. J Clin Endocrinol Metab, 105(7), Article 7. https://doi.org/10.1210/clinem/dgaa190
2019[ to top ]
  • Keller, T., Gorboulev, V., Mueller, T. D., D{\"o}tsch, V., Bernhard, F., & Koepsell, H. Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Mol Pharmacol, 95(2), 169-182. https://doi.org/10.1124/mol.118.113498
  • Scheide-Noeth, J. P., Rosen, M., Baumstark, D., Dietz, H., & Mueller, T. D. Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121. J Mol Biol, 431(4), 714-731. https://doi.org/10.1016/j.jmb.2018.11.029
  • Vissing, J., Johnson, K., T{\"o}pf, A., Nafissi, S., D{\’i}az-Manera, J., French, V. M., Schindler, R. F., Sarathchandra, P., Lokken, N., Rinn{\’e}, S., Freund, M., Decher, N., M{\"u}ller, T., Duno, M., Krag, T., Brand, T., & Straub, V. POPDC3 Gene Variants Associate with a New Form of Limb Girdle Muscular Dystrophy. Ann Neurol, 86(6), 832-843. https://doi.org/10.1002/ana.25620
  • Nickel, J., & Mueller, T. D. Specification of BMP Signaling. Cells, 8(12), Article 12. https://doi.org/10.3390/cells8121579
2018[ to top ]
  • Bertho, S., Herpin, A., Branthonne, A., Jouanno, E., Yano, A., Nicol, B., Muller, T., Pannetier, M., Pailhoux, E., Miwa, M., Yoshizaki, G., Schartl, M., & Guiguen, Y. The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.1803826115
  • Siverino, C., Tabisz, B., L{\"u}hmann, T., Meinel, L., M{\"u}ller, T., Walles, H., & Nickel, J. Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry. J Vis Exp, 133, Article 133. https://doi.org/10.3791/56616
  • Braun, A. C., Gutmann, M., Mueller, T. D., L{\"u}hmann, T., & Meinel, L. Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate. J Control Release, 279, 17-28. https://doi.org/10.1016/j.jconrel.2018.04.009
  • Hedrich, R., Mueller, T. D., Becker, D., & Marten, I. Structure and Function of TPC1 Vacuole SV Channel Gains Shape. Mol Plant. https://doi.org/10.1016/j.molp.2018.03.017
  • Mumcuoglu, D., de Miguel, L., Jekhmane, S., Siverino, C., Nickel, J., Mueller, T. D., van Leeuwen, J. P., van Osch, G. J., & Kluijtmans, S. G. Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2. Mater Sci Eng C Mater Biol Appl, 84, 271-280. https://doi.org/10.1016/j.msec.2017.11.031
  • Nickel, J., Ten Dijke, P., & Mueller, T. D. TGF-β family co-receptor function and signaling. Acta Biochim Biophys Sin (Shanghai), 50(1), 12-36. https://doi.org/10.1093/abbs/gmx126
  • Gorboulev, V., Rehman, S., Albert, C. M., Roth, U., Meyer, M. J., Tzvetkov, M. V., Mueller, T. D., & Koepsell, H. Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake. Mol Pharmacol. https://doi.org/10.1124/mol.117.110767
2017[ to top ]
  • Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K. C., M{\"u}ller, T. D., & Piehler, J. Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments. Nat Commun, 8, 15976-15976. https://doi.org/10.1038/ncomms15976
  • Patino, L., Walton, K. L., Mueller, T., Johnson, K. E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R. B., Laissue, P., & Harrison, C. A. BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9. J Clin Endocrinol Metab, 102(3), 1009-1019.
  • Tabisz, B., Schmitz, W., Schmitz, M., Luehmann, T., Heusler, E., Rybak, J. C., Meinel, L., Fiebig, J. E., Mueller, T. D., & Nickel, J. Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds. Biomacromolecules, 18(3), 695-708. https://doi.org/10.1021/acs.biomac.6b01407
  • Seher, A., Lagler, C., Stühmer, T., Müller-Richter, U. D. A., Kübler, A. C., Sebald, W., Müller, T. D., & Nickel, J. Utilizing BMP-2 muteins for treatment of multiple myeloma. PLOS ONE, 12(5), 1-18. https://doi.org/10.1371/journal.pone.0174884
  • Jodeleit, H., Palamides, P., Beigel, F., Mueller, T., Wolf, E., Siebeck, M., & Gropp, R. Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model. J Transl Med, 15(1), 265-265. https://doi.org/10.1186/s12967-017-1368-4
  • Silva-Vilches, C., Pletinckx, K., Lohnert, M., Pavlovic, V., Ashour, D., John, V., Vendelova, E., Kneitz, S., Zhou, J., Chen, R., Reinheckel, T., Mueller, T. D., Bodem, J., & Lutz, M. B. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion. PLoS One, 12(7), Article 7. https://doi.org/10.1371/journal.pone.0178114
  • Lagler, C., El-Mesery, M., K{\"u}bler, A. C., M{\"u}ller-Richter, U. D. A., St{\"u}hmer, T., Nickel, J., M{\"u}ller, T. D., Wajant, H., & Seher, A. The anti-myeloma activity of bone morphogenetic protein 2 predominantly relies on the induction of growth arrest and is apoptosis-independent. PLoS One, 12(10), Article 10. https://doi.org/10.1371/journal.pone.0185720
  • Lenglet, A., Jaślan, D., Toyota, M., Mueller, M., M{\"u}ller, T., Sch{\"o}nknecht, G., Marten, I., Gilroy, S., Hedrich, R., & Farmer, E. E. Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity. New Phytol, 216(4), 1161-1169. https://doi.org/10.1111/nph.14754
2016[ to top ]
  • Yadin, D., Knaus, P., & Mueller, T. D. Structural insights into BMP receptors: Specificity, activation and inhibition. Cytokine Growth Factor Rev, 27, 13-34. https://doi.org/10.1016/j.cytogfr.2015.11.005
  • Boschert, V., Frisch, C., Back, J. W., van Pee, K., Weidauer, S. E., Muth, E. M., Schmieder, P., Beerbaum, M., Knappik, A., Timmerman, P., & Mueller, T. D. The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin’s binding site for the Wnt co-receptor LRP6. Open Biol, 6(8), Article 8. https://doi.org/10.1098/rsob.160120
  • Hinck, A. P., Mueller, T. D., & Springer, T. A. Structural Biology and Evolution of the TGF-beta Family. Cold Spring Harb Perspect Biol, 8(12), Article 12. https://doi.org/10.1101/cshperspect.a022103
  • Chopra, M., Biehl, M., Steinfatt, T., Brandl, A., Kums, J., Amich, J., Vaeth, M., Kuen, J., Holtappels, R., Podlech, J., Mottok, A., Kraus, S., Jordan-Garrote, A. L., Bauerlein, C. A., Brede, C., Ribechini, E., Fick, A., Seher, A., Polz, J., Ottmuller, K. J., Baker, J., Nishikii, H., Ritz, M., Mattenheimer, K., Schwinn, S., Winter, T., Schafer, V., Krappmann, S., Einsele, H., Muller, T. D., Reddehase, M. J., Lutz, M. B., Mannel, D. N., Berberich-Siebelt, F., Wajant, H., & Beilhack, A. Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion. J Exp Med, 213(9), 1881-900. https://doi.org/10.1084/jem.20151563
  • Schindler, R. F., Scotton, C., Zhang, J., Passarelli, C., Ortiz-Bonnin, B., Simrick, S., Schwerte, T., Poon, K. L., Fang, M., Rinne, S., Froese, A., Nikolaev, V. O., Grunert, C., Muller, T., Tasca, G., Sarathchandra, P., Drago, F., Dallapiccola, B., Rapezzi, C., Arbustini, E., Di Raimo, F. R., Neri, M., Selvatici, R., Gualandi, F., Fattori, F., Pietrangelo, A., Li, W., Jiang, H., Xu, X., Bertini, E., Decher, N., Wang, J., Brand, T., & Ferlini, A. POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest, 126(1), 239-53. https://doi.org/10.1172/JCI79562
  • Bohm, J., Scherzer, S., Krol, E., Kreuzer, I., von Meyer, K., Lorey, C., Mueller, T. D., Shabala, L., Monte, I., Solano, R., Al-Rasheid, K. A., Rennenberg, H., Shabala, S., Neher, E., & Hedrich, R. The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake. Curr Biol, 26(3), 286-95. https://doi.org/10.1016/j.cub.2015.11.057
  • Paarmann, P., Dorpholz, G., Fiebig, J., Amsalem, A. R., Ehrlich, M., Henis, Y. I., Muller, T., & Knaus, P. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling. Int J Biochem Cell Biol, 76, 51-63. https://doi.org/10.1016/j.biocel.2016.04.010
  • Luhmann, T., Spieler, V., Werner, V., Ludwig, M. G., Fiebig, J., Mueller, T. D., & Meinel, L. Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization. Chembiochem, 17(22), 2123-2128. https://doi.org/10.1002/cbic.201600480
2015[ to top ]
  • Bohm, J., Scherzer, S., Shabala, S., Krol, E., Neher, E., Mueller, T. D., & Hedrich, R. Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability. Mol Plant. https://doi.org/10.1016/j.molp.2015.09.017
  • Mueller, T. D. Mechanisms of BMP-Receptor Interaction and Activation. Vitam Horm, 99, 1-61. https://doi.org/10.1016/bs.vh.2015.06.003
  • Mueller, T. D. RGM co-receptors add complexity to BMP signaling. Nat Struct Mol Biol, 22(6), 439-40. https://doi.org/10.1038/nsmb.3037
  • Boschert, V., Muth, E. M., Knappik, A., Frisch, C., & Mueller, T. D. Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097. Acta Crystallogr F Struct Biol Commun, 71(Pt 4), 388-92. https://doi.org/10.1107/S2053230X1500360X
  • Paletta, D., Fichtner, A. S., Hahn, A. M., Starick, L., Beyersdorf, N., Monzon-Casanova, E., Mueller, T. D., & Herrmann, T. The hypervariable region 4 (HV4) and position 93 of the alpha chain modulate CD1d-glycolipid binding of iNKT TCRs. Eur J Immunol, 45(7), 2122-33. https://doi.org/10.1002/eji.201545534
  • Stange, K., Desir, J., Kakar, N., Mueller, T. D., Budde, B. S., Gordon, C. T., Horn, D., Seemann, P., & Borck, G. A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia. Orphanet J Rare Dis, 10, 84. https://doi.org/10.1186/s13023-015-0299-5
  • Klammert, U., Mueller, T. D., Hellmann, T. V., Wuerzler, K. K., Kotzsch, A., Schliermann, A., Schmitz, W., Kuebler, A. C., Sebald, W., & Nickel, J. GDF-5 can act as a context-dependent BMP-2 antagonist. BMC Biol, 13, 77. https://doi.org/10.1186/s12915-015-0183-8
2014[ to top ]
  • Maierhofer, T., Lind, C., Huttl, S., Scherzer, S., Papenfuss, M., Simon, J., Al-Rasheid, K. A., Ache, P., Rennenberg, H., Hedrich, R., Muller, T. D., & Geiger, D. A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective. Plant Cell, 26(6), 2554-2567. https://doi.org/10.1105/tpc.114.125849
  • Tzvetkov, M. V., Seitz, T., Bokelmann, K., Mueller, T., Brockmoller, J., & Koepsell, H. Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?. Blood, 123(9), 1427-9. https://doi.org/10.1182/blood-2013-11-535864
  • Graul-Neumann, L. M., Deichsel, A., Wille, U., Kakar, N., Koll, R., Bassir, C., Ahmad, J., Cormier-Daire, V., Mundlos, S., Kubisch, C., Borck, G., Klopocki, E., Mueller, T. D., Doelken, S. C., & Seemann, P. Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe. European Journal of Human Genetics : EJHG, 22(6), 726-33. https://doi.org/10.1038/ejhg.2013.222
2013[ to top ]
  • Nolte, T., Zadeh-Khorasani, M., Safarov, O., Rueff, F., Gulberg, V., Herbach, N., Wollenberg, A., Mueller, T., Siebeck, M., Wolf, E., & Gropp, R. Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells. Clinical and Experimental Immunology, 172(2), 349-62. https://doi.org/10.1111/cei.12057
  • Sibilski, C., Mueller, T., Kollipara, L., Zahedi, R. P., Rapp, U. R., Rudel, T., & Baljuls, A. Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. The Journal of Biological Chemistry, 288(49), 35237-52. https://doi.org/10.1074/jbc.M113.490235
  • Fiebig, J. E., Weidauer, S. E., Qiu, L. Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J. L., Oschkinat, H., Sebald, W., & Mueller, T. D. The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed. Molecules, 18(10), 11658-82. https://doi.org/10.3390/molecules181011658
  • Mottershead, D. G., Harrison, C. A., Mueller, T. D., Stanton, P. G., Gilchrist, R. B., & McNatty, K. P. Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization. Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2257. https://doi.org/10.1073/pnas.1303459110
  • Boschert, V., van Dinther, M., Weidauer, S., van Pee, K., Muth, E. M., Ten Dijke, P., & Mueller, T. D. Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for wnt-signaling inhibition. PLoS One, 8(11), e81710. https://doi.org/10.1371/journal.pone.0081710
  • van Dinther, M., Zhang, J., Weidauer, S. E., Boschert, V., Muth, E. M., Knappik, A., de Gorter, D. J., van Kasteren, P. B., Frisch, C., Mueller, T. D., & Ten Dijke, P. Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling. PLoS One, 8(4), e62295. https://doi.org/10.1371/journal.pone.0062295
  • Scherzer, S., Krol, E., Kreuzer, I., Kruse, J., Karl, F., von Ruden, M., Escalante-Perez, M., Muller, T., Rennenberg, H., Al-Rasheid, K. A., Neher, E., & Hedrich, R. The Dionaea muscipula Ammonium Channel DmAMT1 Provides NH4(+) Uptake Associated with Venus Flytrap’s Prey Digestion. Current Biology : CB, 23(17), 1649-57. https://doi.org/10.1016/j.cub.2013.07.028
  • Diestel, U., Resch, M., Meinhardt, K., Weiler, S., Hellmann, T. V., Mueller, T. D., Nickel, J., Eichler, J., & Muller, Y. A. Identification of a Novel TGF-beta-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-beta-Receptor-3 (TGFR-3). PLoS One, 8(6), e67214. https://doi.org/10.1371/journal.pone.0067214
  • Laisney, J. A., Mueller, T. D., Schartl, M., & Meierjohann, S. Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops. Oncogene, 32(19), 2403-11. https://doi.org/10.1038/onc.2012.267
2012[ to top ]
  • Egenberger, B., Gorboulev, V., Keller, T., Gorbunov, D., Gottlieb, N., Geiger, D., Mueller, T. D., & Koepsell, H. A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1. J Biol Chem, 287(37), 31561-73. https://doi.org/10.1074/jbc.M112.388793
  • Froese, A., Breher, S. S., Waldeyer, C., Schindler, R. F., Nikolaev, V. O., Rinne, S., Wischmeyer, E., Schlueter, J., Becher, J., Simrick, S., Vauti, F., Kuhtz, J., Meister, P., Kreissl, S., Torlopp, A., Liebig, S. K., Laakmann, S., Muller, T. D., Neumann, J., Stieber, J., Ludwig, A., Maier, S. K., Decher, N., Arnold, H. H., Kirchhof, P., Fabritz, L., & Brand, T. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. J Clin Invest, 122(3), 1119-30. https://doi.org/10.1172/JCI59410
  • Urusova, D. V., Isupov, M. N., Antonyuk, S., Kachalova, G. S., Obmolova, G., Vagin, A. A., Lebedev, A. A., Burenkov, G. P., Dauter, Z., Bartunik, H. D., Lamzin, V. S., Melik-Adamyan, W. R., Mueller, T. D., & Schnackerz, K. D. Crystal structure of D-serine dehydratase from Escherichia coli. Biochim Biophys Acta, 1824(3), 422-32. https://doi.org/10.1016/j.bbapap.2011.10.017
  • Latz, A., Mehlmer, N., Zapf, S., Mueller, T. D., Wurzinger, B., Pfister, B., Csaszar, E., Hedrich, R., Teige, M., & Becker, D. Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium dependent protein kinases (CDPKs). Molecular Plant, 6(4), 1274-1289. https://doi.org/10.1093/mp/sss158
  • Duppatla, V., Gjorgjevikj, M., Schmitz, W., Kottmair, M., Mueller, T. D., & Sebald, W. Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol. Bioconjugate Chemistry, 23(7), 1396-405. https://doi.org/10.1021/bc2004389
  • Back, J. W., Frisch, C., Van Pee, K., Boschert, V., van Vught, R., Puijk, W., Mueller, T. D., Knappik, A., & Timmerman, P. Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin. Protein Eng Des Sel, 25(5), 251-9. https://doi.org/10.1093/protein/gzs012
2011[ to top ]
  • Baljuls, A., Mahr, R., Schwarzenau, I., Muller, T., Polzien, L., Hekman, M., & Rapp, U. R. Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase. J Biol Chem, 286(18), 16491-503. https://doi.org/10.1074/jbc.M110.194167
  • Patino, E., Kotzsch, A., Saremba, S., Nickel, J., Schmitz, W., Sebald, W., & Mueller, T. D. Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha. Structure, 19(12), 1864-75. https://doi.org/10.1016/j.str.2011.08.015
2010[ to top ]
  • Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S. E., de Gorter, D. J., van Bezooijen, R. L., Hatsell, S., Economides, A. N., Mueller, T. D., Lowik, C. W., & ten Dijke, P. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J Biol Chem, 285(53), 41614-26. https://doi.org/10.1074/jbc.M110.153890
  • Piters, E., Culha, C., Moester, M., Van Bezooijen, R., Adriaensen, D., Mueller, T., Weidauer, S., Jennes, K., de Freitas, F., Lowik, C., Timmermans, J. P., Van Hul, W., & Papapoulos, S. First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function. Hum Mutat, 31(7), E1526-43. https://doi.org/10.1002/humu.21274
  • Harth, S., Kotzsch, A., Sebald, W., & Mueller, T. D. Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(Pt 8), 964-8. https://doi.org/10.1107/S1744309110024681
  • Sebald, W., Nickel, J., Zhang, J. L., & Mueller, T. D. Molecular basis of cytokine signalling--theme and variations. FEBS J, 277(1), 106-18. https://doi.org/10.1111/j.1742-4658.2009.07480.x
  • Marcel, D., Muller, T., Hedrich, R., & Geiger, D. K+ transport characteristics of the plasma membrane tandem-pore channel TPK4 and pore chimeras with its vacuolar homologs. FEBS Lett, 584(11), 2433-9. https://doi.org/10.1016/j.febslet.2010.04.038
2009[ to top ]
  • Volk, C., Gorboulev, V., Kotzsch, A., Muller, T. D., & Koepsell, H. Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone. Mol Pharmacol, 76(2), 275-89. https://doi.org/10.1124/mol.109.054783
  • Kotzsch, A., Nickel, J., Sebald, W., & Mueller, T. D. Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB). Acta Crystallogr Sect F Struct Biol Cryst Commun, 65(Pt 8), 779-83. https://doi.org/10.1107/S1744309109024142
  • Filatova, A., Leyerer, M., Gorboulev, V., Chintalapati, C., Reinders, Y., Muller, T. D., Srinivasan, A., Hubner, S., & Koepsell, H. Novel shuttling domain in a regulator (RSC1A1) of transporter SGLT1 steers cell cycle-dependent nuclear location. Traffic, 10(11), 1599-618. https://doi.org/10.1111/j.1600-0854.2009.00982.x
  • Heupel, W. M., Efthymiadis, A., Schlegel, N., Muller, T., Baumer, Y., Baumgartner, W., Drenckhahn, D., & Waschke, J. Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo. J Cell Sci, 122(Pt 10), 1616-25. https://doi.org/10.1242/jcs.040212
  • Spindler, V., Heupel, W. M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Muller, T., Drenckhahn, D., & Waschke, J. Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus. J Biol Chem, 284(44), 30556-64. https://doi.org/10.1074/jbc.M109.024810
  • Heinecke, K., Seher, A., Schmitz, W., Mueller, T. D., Sebald, W., & Nickel, J. Receptor oligomerization and beyond: a case study in bone morphogenetic proteins. BMC Biol, 7, 59. https://doi.org/10.1186/1741-7007-7-59
  • Schmitt, B. M., Gorbunov, D., Schlachtbauer, P., Egenberger, B., Gorboulev, V., Wischmeyer, E., Muller, T., & Koepsell, H. Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine. Am J Physiol Renal Physiol, 296(4), F709-22. https://doi.org/10.1152/ajprenal.90323.2008
  • Heupel, W. M., Muller, T., Efthymiadis, A., Schmidt, E., Drenckhahn, D., & Waschke, J. Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus. J Biol Chem, 284(13), 8589-95. https://doi.org/10.1074/jbc.M808813200
  • Kotzsch, A., Nickel, J., Seher, A., Sebald, W., & Muller, T. D. Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. EMBO J, 28(7), 937-47. https://doi.org/10.1038/emboj.2009.37
  • Spindler, V., Heupel, W.-M., Efthymiadis, A., Schmidt, E., Eming, R., Rankl, C., Hinterdorfer, P., Müller, T., Drenckhahn, D., & Waschke, J. Desmocollin 3-mediated Binding Is Crucial for Keratinocyte Cohesion and Is Impaired in Pemphigus. Journal of Biological Chemistry, 284(44), 30556-30564. https://doi.org/10.1074/jbc.m109.024810
2008[ to top ]
  • Zhang, J. L., Qiu, L. Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W., & Mueller, T. D. Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding. Dev Cell, 14(5), 739-50. https://doi.org/10.1016/j.devcel.2008.02.017
  • Qiu, L. Y., Zhang, J. L., Kotzsch, A., Sebald, W., & Mueller, T. D. Crystallization and preliminary X-ray analysis of the complex of the first von Willebrand type C domain bound to bone morphogenetic protein 2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 64(Pt 4), 307-12. https://doi.org/10.1107/S1744309108006945
  • Kotzsch, A., Nickel, J., Seher, A., Heinecke, K., van Geersdaele, L., Herrmann, T., Sebald, W., & Mueller, T. D. Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J Biol Chem, 283(9), 5876-87. https://doi.org/10.1074/jbc.M706029200
  • Klages, J., Kotzsch, A., Coles, M., Sebald, W., Nickel, J., Muller, T., & Kessler, H. The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding. Biochemistry, 47(46), 11930-9. https://doi.org/10.1021/bi801059j
2007[ to top ]
  • Weber, D., Kotzsch, A., Nickel, J., Harth, S., Seher, A., Mueller, U., Sebald, W., & Mueller, T. D. A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. BMC Struct Biol, 7, 6. https://doi.org/10.1186/1472-6807-7-6
  • Voss, K., Stahl, S., Schleider, E., Ullrich, S., Nickel, J., Mueller, T. D., & Felbor, U. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics, 8(4), 249-56. https://doi.org/10.1007/s10048-007-0098-9
  • Baljuls, A., Mueller, T., Drexler, H. C., Hekman, M., & Rapp, U. R. Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates. J Biol Chem, 282(36), 26575-90. https://doi.org/10.1074/jbc.M702429200
  • Sebald, W., Nickel, J., Seher, A., & Mueller, T. Bone morphogenetic proteins. In E. Baeuerlein, M. Epple, P. Behrens, & W. Pompe (Eds.), Handbook of Biomineralization (pp. 19-34). Wiley-VCH Verlag GmbH Co. KGaA.
  • Mueller, T., & Sebald, W. Wie BMPs (bone morphogenetic proteins) ihre Rezeptoren binden und aktivieren. BIOspektrum, 3, 236-239.
2006[ to top ]
  • Kraich, M., Klein, M., Patino, E., Harrer, H., Nickel, J., Sebald, W., & Mueller, T. D. A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. BMC Biol, 4, 13. https://doi.org/10.1186/1741-7007-4-13
  • Meierjohann, S., Mueller, T., Schartl, M., & Buehner, M. A structural model of the extracellular domain of the oncogenic EGFR variant Xmrk. Zebrafish, 3(3), 359-69. https://doi.org/10.1089/zeb.2006.3.359
2005[ to top ]
  • Nickel, J., Kotzsch, A., Sebald, W., & Mueller, T. D. A single residue of GDF-5 defines binding specificity to BMP receptor IB. J Mol Biol, 349(5), 933-47. https://doi.org/10.1016/j.jmb.2005.04.015
  • Stahl, S., Gaetzner, S., Mueller, T. D., & Felbor, U. Endostatin phenylalanines 31 and 34 define a receptor binding site. Genes Cells, 10(9), 929-39. https://doi.org/10.1111/j.1365-2443.2005.00890.x
2004[ to top ]
  • Johansson, C., Finger, L. D., Trantirek, L., Mueller, T. D., Kim, S., Laird-Offringa, I. A., & Feigon, J. Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target. J Mol Biol, 337(4), 799-816. https://doi.org/10.1016/j.jmb.2004.01.056
2003[ to top ]
  • Sebald, W., & Mueller, T. D. The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly. Trends Biochem Sci, 28(10), 518-21. https://doi.org/10.1016/j.tibs.2003.08.001
  • Mueller, T. D., & Feigon, J. Structural determinants for the binding of ubiquitin-like domains to the proteasome. EMBO J, 22(18), 4634-45. https://doi.org/10.1093/emboj/cdg467
2002[ to top ]
  • Mueller, T. D., & Feigon, J. Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J Mol Biol, 319(5), 1243-55. https://doi.org/10.1016/S0022-2836(02)00302-9
  • Mueller, T. D., Zhang, J. L., Sebald, W., & Duschl, A. Structure, binding, and antagonists in the IL-4/IL-13 receptor system. Biochim Biophys Acta, 1592(3), 237-50. http://www.ncbi.nlm.nih.gov/pubmed/12421669
2000[ to top ]
  • Withers-Ward, E. S., Mueller, T. D., Chen, I. S., & Feigon, J. Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr. Biochemistry, 39(46), 14103-12. http://www.ncbi.nlm.nih.gov/pubmed/11087358
1997[ to top ]
  • Shaw, G. L., Muller, T., Campbell, I. D., Mott, H. R., Oschkinat, H., & Mitschang, L. Constant-time HQQC experiment for protein NMR spectroscopy. Journal of Magnetic Resonance, 124(2), 479-483. https://doi.org/Doi 10.1006/Jmre.1996.1062
1995[ to top ]
  • Muller, T., Oehlenschlager, F., & Buehner, M. Human Interleukin-4 and Variant R88q - Phasing X-Ray-Diffraction Data by Molecular Replacement Using X-Ray and Nuclear-Magnetic-Resonance Models. Journal of Molecular Biology, 247(2), 360-372. https://doi.org/Doi 10.1006/Jmbi.1994.0144
  • Duschl, A., Muller, T., & Sebald, W. Antagonistic mutant proteins of interleukin-4. Behring Inst Mitt, 96, 87-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7575356
1994[ to top ]
  • Muller, T., Dieckmann, T., Sebald, W., & Oschkinat, H. Aspects of Receptor-Binding and Signaling of Interleukin-4 Investigated by Site-Directed Mutagenesis and Nmr-Spectroscopy. Journal of Molecular Biology, 237(4), 423-436. https://doi.org/Doi 10.1006/Jmbi.1994.1245
  • Muller, T., Sebald, W., & Oschkinat, H. Antagonist Design through Forced Electrostatic Mismatch. Nature Structural Biology, 1(10), 674-676. https://doi.org/Doi 10.1038/Nsb1094-674
1993[ to top ]
  • Kruse, N., Shen, B. J., Arnold, S., Tony, H. P., Muller, T., & Sebald, W. 2 Distinct Functional Sites of Human Interleukin-4 Are Identified by Variants Impaired in Either Receptor-Binding or Receptor Activation. Embo Journal, 12(13), 5121-5129. /brokenurl#<Go to ISI>://WOS:A1993MM12000024