Startpage - Lehrstuhl für Mikrobiologie

Chair of Microbiology

In the focus of research at the Chair of Microbiology are pathogenicity mechanisms of different microorganisms such as Neisseria gonorrhoeae, Chlamydia trachomatis, Bordetella pertussis and Staphylococcus aureus.

Host-pathogen interactions, pathogen-induced host cell apoptosis as well as the interface of infection and cancer are of peticular interest.

Follow this link to find out more about our research.

News

Polymorph-nukleare Leukozyten infiziert mit Chlamydia trachomatis (hier blau gefärbt). (Foto: Karthika Rajeeve)

Blockade at the Receptor

When Chlamydia attacks the human body the immune system starts its defence mechanisms. But the bacteria find a way to defend themselves. Scientists from Würzburg have deciphered new details of their strategy now.

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[Translate to Englisch:] Welcome-picture

Microbe of the year 2019: Magnetospirillum

Newest Publications

Gulve N, Prusty BK, Rudel T. Chlamydia trachomatis Impairs Host Base Excision Repair by Downregulating Polymerase Beta. Cell Microbiol. 2018 Nov 24:e12986. doi: 10.1111/cmi.12986
Prusty BK, Gulve N, Chowdhury SR, Schuster M, Strempel S, Descamps V, Rudel T. HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation. NPJ Genom Med. 2018 Sep 5;3:25. doi: 10.1038/s41525-018-0064-5.
Horn J, Klepsch M, Manger M, Wolz C, Rudel T, Fraunholz M. The long non-coding RNA SSR42 controls Staphylococcus aureus α-toxin transcription in response to environmental stimuli. J Bacteriol. 2018 Aug 27. pii: JB.00252-18. doi: 10.1128/JB.00252-18.
Fischer A, Rudel T. Safe haven under constant attack-The Chlamydia-containing vacuole. Cell Microbiol. 2018 Aug 12:e12940. doi: 10.1111/cmi.12940.
Rajeeve K, Das S, Prusty BK, Rudel T. Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response. Nat Microbiol. 2018 Jul;3(7):824-835. doi: 10.1038/s41564-018-0182-y.

Prusty BK, Chowdhury SR, Gulve N, Rudel T. Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity. Front Cell Infect Microbiol. 2018 May 30;8:183.

Thakur C, Rapp UR, Rudel T. Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer. Oncotarget. 2017 Dec 30;9(5):6518-6535. doi: 10.18632/oncotarget.23785

Nadella V, Mohanty A, Sharma L, Yellaboina S, Mollenkopf HJ, Mazumdar VB, Palaparthi R, Mylavarapu MB, Maurya R, Kurukuti S, Rudel T, Prakash H. Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses. Front Immunol. 2018 Jan 9;8:1792. doi: 10.3389/fimmu.2017.01792.

Horn J, Stelzner K, Rudel T, Fraunholz M. Inside job: Staphylococcus aureus host-pathogen interactions. Int J Med Microbiol. 2017 Nov 26. pii: S1438-4221(17)30316-8. doi: 10.1016/j.ijmm.2017.11.009.