Chair of Cell and Developmental Biology (Zoology I)

Manfred Alsheimer - publications

Manfred Alsheimer



Zhang, J., Ruiz, M., Bergh, P.-O., Henricsson, M., Stojanović, N., Devkota, R., Henn, M., Bohlooly-Y, M., Hernández-Hernández, A., Alsheimer, M., Borén, J., Pilon, M., and Shibuya, H. (2024). Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat. Commun. 5, 2315. doi: 10.1038/s41467-024-46718-6


Thoma, H., Grünewald, L., Braune, S., Pasch, E., and Alsheimer, M. (2023). SUN4 is a spermatid type II inner nuclear membrane protein that forms heteromeric assemblies with SUN3 and interacts with lamin B3. J. Cell Sci. 136, jcs.260155.


Dedukh, D., da Cruz, I., Kneitz, S., Marta, A., Ormanns, J., Tichopád, T., Lu, Y., Alsheimer, M., Janko, K., and Schartl, M. (2022). Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa. Chromosome Res. 30, 443–457. doi: 10.1007/s10577-022-09708-2.

Nanda, I., Schories, S., Simeonov, I., Adolfi, M.C., Du, K., Steinlein, C., Alsheimer, M., Haaf, T., and Schartl, M. (2022). Evolution of the Degenerated Y-Chromosome of the Swamp Guppy, Micropoecilia picta. Cells 11, 1118. doi: 10.3390/cells11071118


Koncicka, M., Cervenka, J., Jahn, D., Sucha, R., Vodicka, P., Gad, A., Alsheimer, M., and Susor, A. (2020). Expression of lamin C2 in mammalian oocytes. PLoS ONE 15, e0229781. doi: 10.1371/journal.pone.0229781

Gao, Q., Khan, R., Yu, C., Alsheimer, M., Jiang, X., Ma, H., and Shi, Q. (2020). The testis specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis. J. Biol. Chem. 295, 6289-6298. doi: 10.1074/jbc.RA119.012375


Levy,Y., Ross, J.A., Niglas, M., Snetkov, V.A., Lynham, S., Liao, C.-Y., Puckelwartz, M.J., Hsu, Y.-M., McNally, E.M., Alsheimer, M., Harridge, S.D.R., Young, S.G., Fong, L.G., Español, Y., Lopez-Otin, C., Kennedy, B.K., Lowe, D.A., and Ochala J. (2018). Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness. JCI Insight 3, e120920. doi: 10.1172/jci.insight.120920

Link, J., Paouneskou, D., Velkova, M., Daryabeigi, A., Laos, T., Labella, S., Barroso, C., Pacheco Piñol, S., Montoya, A., Kramer, H., Woglar, A., Baudrimont, A., Markert, S.M., Stigloher,C., Martinez-Perez, E., Dammermann, A., Alsheimer, M., Zetka, M., and Jantsch, V. (2018).Transient and partial nuclear lamina disruption promotes chromosome movement in early meiotic prophase. Dev. Cell 45, 212-225. doi: 10.1016/j.devcel.2018.03.018


Link, J., Benavente, R., and Alsheimer, M. (2016). Analysis of Meiotic Telomere Behavior in the Mouse. Methods Mol. Biol. 1411, 195-208. doi: 10.1007/978-1-4939-3530-7_12

Fraune, J., Brochier-Armanet, C., Alsheimer, M., Volff J.N., Schücker, K., and Benavente, R. (2016). Evolutionary history of the mammalian synaptonemal complex. Chromosoma 125, 355-360. doi: 10.1007/s00412-016-0583-8

Gómez, R., Felipe-Medina, N., Ruiz-Torres, M., Berenguer, I., Viera, A., Pérez, S., Barbero, J.L., Llano, E., Fukuda, T., Alsheimer, M., Pendás, A. M., Losada, A., and Suja, J.A. (2016). Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes. EMBO Rep 17, 695-707. doi: 10.15252/embr.201541060


Pasch, E., Link, J., Beck, C., Scheuerle, S., and Alsheimer, M. (2015). The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility. Biol. Open 4, 1792-1802.doi: 10.1242/bio.015768

Link, J., Jahn, D., and Alsheimer, M. (2015). Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements. Nucleus 6, 93-101. doi: 10.1080/19491034.2015.1004941

Viera, A., Alsheimer, M., Gómez, R., Berenguer, I., Ortega, S., Symonds, C.E., Santamaría, D., Benavente, R., and Suja, J.A. (2015). CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J. Cell Sci. 128, 88-99. doi: 10.1242/jcs.154922


Fraune, J., Alsheimer, M., Redolfi, J., Brochier-Armanet, C., and Benavente, R. (2014). Protein SYCP2 Is an Ancient Component of the Metazoan Synaptonemal Complex. Cytogenet. Genome Res. 144, 299-305. doi: 10.1159/000381080

de la Fuente, R., Manterola, M., Viera, A., Parra, M.T., Alsheimer, M., Rufas, J.S., and Page, J. (2014). Chromatin organization and remodeling of interstitial telomeric sites during meiosis in the Mongolian Gerbil (Meriones unguiculatus). Genetics 197, 1137-1151.   doi: 10.1534/genetics.114.166421

Daniel, K., Tränkner, D., Wojtasz, L., Shibuya, H., Watanabe, Y., Alsheimer, M., and Tóth, A. (2014). Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein. BMC Cell Biology 15, 17. doi: 10.1186/1471-2121-15-17

Link, J., Leubner, M., Schmitt, J., Göb, E., Benavente, R., Jeang, K.-T., Xu, R., and Alsheimer, M. (2014). Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. PLoS Genet. 10, e1004099. doi: 10.1371/journal.pgen.1004099


Fraune, J., Brochier-Armanet, C., Alsheimer, M., and Benavente, R. (2013). Phylogenies of Central Element Proteins Reveal the Dynamic Evolutionary History of the Mammalian Synaptonemal Complex: Ancient and Recent Components. Genetics 195, 781-793. doi: 10.1534/genetics.113.156679

Gómez, R., Jordan, P.W., Viera, A., Alsheimer, M., Fukuda, T., Jessberger, R., Llano, E., Pendás, A.M., Handel, M.A., and Suja, J.A. (2013). Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis implies functions in distinct chromosome processes. J. Cell Sci. 126, 4239-4252. doi: 10.1242/jcs.130195

Link, J., Jahn, D., Schmitt, J., Göb, E., Baar, J., Ortega, S., Benavente, R., and Alsheimer, M. (2013). The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse. PLoS Genet. 9, e1003261. doi: 10.1371/journal.pgen.1003261

Kracklauer, M.P., Link, J., and Alsheimer, M. (2013). LINCing the Nuclear Envelope to Gametogenesis. Curr. Top. Dev. Biol. 102, 127-157. doi: 10.1016/B978-0-12-416024-8.00005-2


Fraune, J.1, Alsheimer, M.1*, Volff, J.N., Busch, K., Fraune, S., Bosch, T.C.G., and Benavente, R.* (2012). Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans. Proc. Natl. Acad. Sci. USA 109, 16588-16593. doi: 10.1073/pnas.1206875109

Jahn, D., Schramm, S., Schnölzer, M., Heilmann, C.J., de Koster, C.G., Schütz, W., Benavente, R., and Alsheimer, M. (2012). A truncated lamin A in the Lmna (-/-) mouse line: Implications for the understanding of laminopathies. Nucleus 3, 463-474. doi: 10.4161/nucl.21676

Fraune, J., Schramm, S., Alsheimer, M., and Benavente, R. (2012). The mammalian synaptonemal complex: Protein components, assembly and role in meiotic recombination. Exp. Cell Res. 318, 1340-1346. doi: 10.1016/j.yexcr.2012.02.018


Göb, E., Meyer-Natus, E., Benavente, R., and Alsheimer, M. (2011). Expression of individual mammalian Sun1 isoforms depends on the cell type. Commun. Integr. Biol. 4, 440-442. doi: 10.4161/cib.15369

Schramm, S., Fraune, J., Naumann, R., Hernandez-Hernandez, A., Höög, C., Cooke, H. J., Alsheimer, M.*, and Benavente, R.* (2011). A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination and fertility. PLoS Genet. 7, e1002088. doi: 10.1371/journal.pgen.1002088

Alsheimer, M., Jahn, D. Schramm, S., and Benavente, R. (2011). Nuclear lamins in mammalian spermatogenesis. In Epigenetics and Human Reproduction, S. Rousseaux and S. Khochbin eds. (Berlin Heidelberg, Germany: Springer-Verlag), pp. 279-288. doi: 10.1007/978-3-642-14773-9_12


Göb, E., Schmitt, J., Benavente, R., and Alsheimer, M. (2010). Mammalian sperm head formation involves different polarization of two novel LINC complexes. PLoS ONE 5, e12072. doi: 10.1371/journal.pone.0012072

Jahn, D., Schramm, S., Benavente, R., and Alsheimer, M. (2010). Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity. Nucleus 1, 273-283. doi: 10.4161/nucl.11800

Alsheimer, M., Baier, A., Schramm, S., Schütz, W., and Benavente, R. (2010). Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution. Cytogenet. Genome Res. 128, 162-168. doi: 10.1159/000303341


Adelfalk, C., Janschek, J., Revenkova, E., Liebe, B., Göb, E., Alsheimer, M., Benavente, R., de Boer, E., Novak, I., Höög, C., Scherthan, H., and Jessberger, R. (2009). Cohesin SMC1beta protects telomeres in meiocytes. J. Cell Biol. 187, 185-199.  doi: 10.1083/jcb.200808016

Winkel, K., Alsheimer, M.*, Öllinger, R., and Benavente, R.* (2009). Protein SYCP2 provides a link between transverse filaments and lateral elements of mammalian synaptonemal complexes. Chromosoma: 118, 259-267. doi: 10.1007/s00412-008-0194-0

Alsheimer, M. (2009). The dance floor of meiosis: Evolutionary conservation of nuclear envelope attachment and dynamics of meiotic telomeres. Genome Dyn. 5, 81-93. doi: 10.1159/000166621


Schmitt, J., Benavente, R., Hodzic, D., Höög, C., Stewart, C.L., and Alsheimer, M. (2007). Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope. Proc. Natl. Acad. Sci. USA 104, 7426-7431. doi: 10.1073/pnas.0609198104

Baier, A.1, Alsheimer, M.1, Volff, J.N., and Benavente, R. (2007). Synaptonemal Complex Protein SYCP3 of the Rat: Evolutionary Conserved Domains and the Assembly of Higher Order Structures. Sex. Dev. 1, 161-168. doi: 10.1159/000102105

Baier, A., Alsheimer, M., and Benavente, R. (2007). Synaptonemal complex protein SYCP3: Conserved polymerization properties among vertebrates. BBA – Proteins Proteom. 1774,: 595-602. doi:10.1016/j.bbapap.2007.03.008


Costa, Y., Speed, R., Öllinger, R., Alsheimer, M., Semple, C.A., Gautier, P., Maratou, K., Novak, I., Höög, C., Benavente, R., and Cooke, H.J. (2005). Two novel proteins recruited by SYCP1 are at the centre of meiosis. J. Cell Sci. 118, 2755-2762. doi: 10.1242/jcs.02402

Schütz, W., Benavente, R., and Alsheimer, M. (2005). Dynamic properties of germline-specific lamin B3: the role of the shortened rod domain. Eur. J. Cell Biol. 84, 649-662. doi:10.1016/j.ejcb.2005.03.001

Schütz, W., Alsheimer, M., Öllinger, R., and Benavente, R. (2005). Nuclear envelope remodelling during mouse spermiogenesis: Postmeiotic expression and redistribution of germline lamin B3. Exp. Cell Res. 307, 285-291. doi: 10.1016/j.yexcr.2005.03.023

Prüfert, K., Alsheimer, M., Benavente, R., and Krohne, G. (2005). The myristoylation site of meiotic lamin C2 promotes local nuclear membrane growth and the formation of intranuclear membranes in somatic cultured cells. Eur. J. Cell Biol. 84, 637-646. doi: 10.1016/j.ejcb.2004.12.027

Geisinger, A., Alsheimer, M., Baier, A., Benavente, R., and Wettstein, R. (2005). The mammalian gene pecanex 1 is differentially expressed during spermatogenesis. BBA – Gene Struct. Expr. 1728, 34-43.doi: 10.1016/j.bbaexp.2005.01.010

Alsheimer, M.*, Drewes, T., Schütz, W., and Benavente, R. (2005). The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa. Eur. J. Cell Biol. 84, 445-452. doi: 10.1016/j.ejcb.2004.11.003

Öllinger, R., Alsheimer, M., and Benavente, R. (2005). Mammalian Protein SCP1 Forms Synaptonemal Complex-like Structures in the Absence of Meiotic Chromosomes. Mol. Biol. Cell. 16, 212-217. doi: 10.1091/mbc.E04-09-077


Alsheimer, M., Liebe, B., Sewell, L., Stewart, C.L., Scherthan, H., and Benavente, R. (2004). Disruption of spermatogenesis in mice lacking A-type lamins. J. Cell Sci. 117, 1173-1178. doi: 10.1242/jcs.00975

Liebe, B.1, Alsheimer, M.1, Höög, C., Benavente, R., and Scherthan, H. (2004). Telomere attachment, meiotic chromosome condensation, pairing, and bouquet stage duration are modified in spermatocytes lacking axial elements. Mol. Biol. Cell 15, 827-837. doi: 10.1091/mbc.E03-07-0524

Benavente, R., Alsheimer, M., and von Glasenapp, E. (2004). The nuclear envelope at the attachment sites of mammalian meiotic telomeres. Chromosomes Today 14, 119-126. link out


Franco, S.1, Alsheimer, M.1, Herrera, E., Benavente, R., and Blasco, M.A. (2002). Mammalian meiotic telomeres: composition and ultrastructure in telomerase-deficient mice. Eur. J. Cell Biol. 81, 335-340. doi: 10.1078/0171-9335-00259


Alsheimer, M., von Glasenapp, E., Schnölzer, M., Heid H., and Benavente, R. (2000). Meiotic lamin C2: the unique amino-terminal hexapeptide GNAEGR is essential for nuclear envelope association. Proc. Natl. Acad. Sci. USA. 97, 13120-13125. doi: 10.1073/pnas.240466597


Alsheimer, M., von Glasenapp, E., Hock, R., and Benavente, R. (1999). Architecture of the nuclear periphery of rat pachytene spermatocytes: Distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites. Mol. Biol. Cell 10, 1235-1245. doi: 10.1091/mbc.10.4.1235

Lang, C., Paulin-Levasseur, M., Gajewski, A., Alsheimer, M., Benavente, R., and Krohne, G. (1999). Molecular characterization and developmentally regulated expression of Xenopus lamina–associated polypeptid 2 (XLAP2). J. Cell Sci. 112, 749-759. PMID: 9973608


Alsheimer, M., Fecher, E., and Benavente, R. (1998). Nuclear envelope remodelling during rat spermiogenesis: Distribution and expression pattern of LAP2/thymopoietins. J. Cell Sci. 111, 2227-2234. PMID: 9664044


Alsheimer, M., Imamichi, Y., Heid, H., and Benavente, R. (1997). Molecular characterization and expression pattern of XY body-associated protein XY40 of the rat. Chromosoma 106, 308-314. doi: 10.1007/s004120050252


Alsheimer, M., and Benavente, R. (1996). Change of karyoskeleton during mammalian spermatogenesis: expression pattern of nuclear lamin C2 and its regulation. Exp. Cell Res. 228, 181-188. doi: 10.1006/excr.1996.0315