Chair of Cell and Developmental Biology (Zoology I)


    Full list of publications

    Bachmaier, S, Santos YV, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG,
    Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E & Boshart M. (2019) Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun 10, 1421. PMID:30926779

    Goos C, Dejung M, Wehman AM, Meyer-Natus E, Schmidt J, SunterJ , Engstler M, Butter F and Kramer S. (2019) Trypanosomes can initiate nuclear export co-transcriptionally. Nucleic Acid research 47, 266-282. PMID:30418648

    Kramer S and McLennan AG. (2018) The complex enzymology of mRNA decapping: enzymes of four classes cleave pyrophosphate bounds. WIREs RNA 38, e1511–17. PMID:30345629

    Zoltner, M., Krienitz, N., Field, M. C. & Kramer, S (2018). Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PLoS Necl Trop Dis 12, e0006679. PMID:30040867

    Bannerman, B P, Kramer, S, Dorrell, R . & Carrington, M (2018) Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism. PLoS ONE 13, e0192633–23. PMID:29561870

    Kramer S (2017) The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. PLoS Pathog 13: e1006456 PMID:28628654

    Zimmermann, H., Subota, I., Batram, C., Kramer, S., Janzen, C. J., Jones, N. G., & Engstler, M. (2017). A quorum sensing-independent path to stumpy development in Trypanosoma brucei. PLoS Pathog., 13:e1006324–33. PMID:28394929

    Kramer S (2017) Simultaneous detection of mRNA transcription and decay intermediates by dual colour single mRNA FISH on subcellular resolution. Nucleic Acids Res 45: e49 PMID:27940558

    Goos C, Dejung M, Janzen CJ, Butter F and Kramer S (2017) The nuclear proteome of Trypanosoma brucei. PLoS One 12(7):e0181884. PMID:28727848

    Kramer S, Piper S, Estevez A, Carrington M. (2016)Polycistronic trypanosome mRNAs are a target for the exosome. Mol Biochem Parasitol 205:1–5. PMID:26946399

    Fritz M, Vanselow J, Sauer N, Lamer S, Goos C, Siegel TN, Subota I, Schlosser A, Carrington M and Kramer S. (2015) Novel insights into RNP granules by employing the trypanosome’s microtubule skeleton as a molecular sieve. Nucleic Acids Res 43:8013–8032. PMID:26187993

    Kramer S, Carrington M. (2014)An AU-rich instability element in the 3’UTR mediates an increase in mRNA stability in response to expression of a dhh1 ATPase mutant. Translation 2: e28587 PMID:26779405

    Kramer S. (2014)RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa. Wiley interdisciplinary reviews RNA 5: 263-284. PMID:24339376

    Krüger T, Hofweber M, Kramer S. (2013)SCD6 induces ribonucleoprotein granule formation in trypanosomes in a translation-independent manner, regulated by its Lsm and RGG domains. Mol Biol Cell 24: 2098-2111. PMID:23676662

    Kramer S, Bannerman-Chukualim B, Ellis L, Boulden EA, Kelly S, Field MC, Carrington M. (2013)Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools. PLoS One 8: e54004. PMID:23382864

    Kelly S, Kramer S, Schwede A, Maini PK, Gull K, Carrington M. (2012)Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes. Open Biol 2: 120033. PMID:22724062

    Kramer S. (2012)Developmental regulation of gene expression in the absence of transcriptional control: the case of kinetoplastids. Mol Biochem Parasitol 181: 61-72. PMID:22019385

    Kramer S, Marnef A, Standart N, Carrington M. (2012)Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci 125: 2896-2909. PMID:22366449

    Fernandez-Moya SM, Garcia-Perez A, Kramer S, Carrington M, Estevez AM. (2012)Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei. PLoS One 7: e48870. PMID:23145003

    Schwede A, Kramer S, Carrington M. (2012)How do trypanosomes change gene expression in response to the environment?  Protoplasma 249: 223-238. PMID:21594757

    Kramer S, Carrington M. (2011)Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids. Trends Parasitol 27: 23-30. PMID:20609625

    Kramer S, Kimblin NC, Carrington M. (2010)Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. BMC genomics 11: 283. PMID:20444260

    Kramer S, Queiroz R, Ellis L, Hoheisel JD, Clayton C, Carrington M. (2010)The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci 123: 699-711. PMID:20124414

    Smith TK, Vasileva N, Gluenz E, Terry S, Portman N, Kramer S, Carrington M, Michaeli S, Gull K, Rudenko G. (2009)Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS ONE 4: e7532. PMID:19855834

    Kramer S, Queiroz R, Ellis L, Webb H, Hoheisel JD, Clayton C, Carrington M. (2008)Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci 121: 3002-3014. PMID:18713834

    Hammarton TC, Kramer S, Tetley L, Boshart M, Mottram JC. (2007)Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis. Molecular microbiology 65: 1229-1248. PMID:17662039

    Kelly S, Reed J, Kramer S, Ellis L, Webb H, Sunter J, Salje J, Marinsek N, Gull K, Wickstead B et al.  (2007)Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol 154: 103-109. PMID:17512617

    Kramer S, Klöckner T, Selmayr M, Boshart M. (2007)Interstrain sequence comparison, transcript map and clonal genomic rearrangement of a 28 kb locus on chromosome 9 of Trypanosoma brucei. Mol Biochem Parasitol 151: 129-132. PMID:17112605