Lehrstuhl für Zell- und Entwicklungsbiologie


Full list of publications

Kramer,S., Karolak,N.K., Odenwald,J., Gabiatti,B., Castañeda Londoño,P.A., Zavřelová,A., Freire,E.R., Almeida,K.S., Braune,S., Moreira,C., et al. (2023) A unique mRNA decapping complex in trypanosomes. Nucleic Acids Res., 10.1093/nar/gkad497. PMID37309887

Moreira, C. M. do N. et al. (2022) Impact of inherent biases built into proteomic techniques: Proximity labeling and affinity capture compared. J Biol Chem 102726  PMID: 36410438

Londono, P. A. C., Banholzer, N., Bannerman, B. P. & Kramer, S. (2021) Is mRNA decapping activity of ApaH like phosphatases (ALPH’s) the reason for the loss of cytoplasmic ALPH’s in all eukaryotes but Kinetoplastida? doi:10.21203/rs.3.rs-192222/v1. PMID: 34162332

Kramer, S., Meyer-Natus, E., Stigloher, C., Thoma, H., Schnaufer, A. and Engstler M. (2020) Parallel monitoring of RNA abundance, localisation and compactness with correlative single molecule FISH on LR White embedded samples. Nucleic Acids Res 49, gkaa1142- PMID: 33275141

Bachmaier, S, Santos YV, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG,
Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E & Boshart M. (2019) Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun 10, 1421. PMID:30926779

Goos C, Dejung M, Wehman AM, Meyer-Natus E, Schmidt J, SunterJ , Engstler M, Butter F and Kramer S. (2019) Trypanosomes can initiate nuclear export co-transcriptionally. Nucleic Acid research 47, 266-282. PMID:30418648

Kramer S and McLennan AG. (2018) The complex enzymology of mRNA decapping: enzymes of four classes cleave pyrophosphate bounds. WIREs RNA 38, e1511–17. PMID:30345629

Zoltner, M., Krienitz, N., Field, M. C. & Kramer, S (2018). Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA. PLoS Necl Trop Dis 12, e0006679. PMID:30040867

Bannerman, B P, Kramer, S, Dorrell, R . & Carrington, M (2018) Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism. PLoS ONE 13, e0192633–23. PMID:29561870

Kramer S (2017) The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. PLoS Pathog 13: e1006456 PMID:28628654

Zimmermann, H., Subota, I., Batram, C., Kramer, S., Janzen, C. J., Jones, N. G., & Engstler, M. (2017). A quorum sensing-independent path to stumpy development in Trypanosoma brucei. PLoS Pathog., 13:e1006324–33. PMID:28394929

Kramer S (2017) Simultaneous detection of mRNA transcription and decay intermediates by dual colour single mRNA FISH on subcellular resolution. Nucleic Acids Res 45: e49 PMID:27940558

Goos C, Dejung M, Janzen CJ, Butter F and Kramer S (2017) The nuclear proteome of Trypanosoma brucei. PLoS One 12(7):e0181884. PMID:28727848

Kramer S, Piper S, Estevez A, Carrington M. (2016)Polycistronic trypanosome mRNAs are a target for the exosome. Mol Biochem Parasitol 205:1–5. PMID:26946399

Fritz M, Vanselow J, Sauer N, Lamer S, Goos C, Siegel TN, Subota I, Schlosser A, Carrington M and Kramer S. (2015) Novel insights into RNP granules by employing the trypanosome’s microtubule skeleton as a molecular sieve. Nucleic Acids Res 43:8013–8032. PMID:26187993

Kramer S, Carrington M. (2014)An AU-rich instability element in the 3’UTR mediates an increase in mRNA stability in response to expression of a dhh1 ATPase mutant. Translation 2: e28587 PMID:26779405

Kramer S. (2014)RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa. Wiley interdisciplinary reviews RNA 5: 263-284. PMID:24339376

Krüger T, Hofweber M, Kramer S. (2013)SCD6 induces ribonucleoprotein granule formation in trypanosomes in a translation-independent manner, regulated by its Lsm and RGG domains. Mol Biol Cell 24: 2098-2111. PMID:23676662

Kramer S, Bannerman-Chukualim B, Ellis L, Boulden EA, Kelly S, Field MC, Carrington M. (2013)Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools. PLoS One 8: e54004. PMID:23382864

Kelly S, Kramer S, Schwede A, Maini PK, Gull K, Carrington M. (2012)Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes. Open Biol 2: 120033. PMID:22724062

Kramer S. (2012)Developmental regulation of gene expression in the absence of transcriptional control: the case of kinetoplastids. Mol Biochem Parasitol 181: 61-72. PMID:22019385

Kramer S, Marnef A, Standart N, Carrington M. (2012)Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci 125: 2896-2909. PMID:22366449

Fernandez-Moya SM, Garcia-Perez A, Kramer S, Carrington M, Estevez AM. (2012)Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei. PLoS One 7: e48870. PMID:23145003

Schwede A, Kramer S, Carrington M. (2012)How do trypanosomes change gene expression in response to the environment?  Protoplasma 249: 223-238. PMID:21594757

Kramer S, Carrington M. (2011)Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids. Trends Parasitol 27: 23-30. PMID:20609625

Kramer S, Kimblin NC, Carrington M. (2010)Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. BMC genomics 11: 283. PMID:20444260

Kramer S, Queiroz R, Ellis L, Hoheisel JD, Clayton C, Carrington M. (2010)The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci 123: 699-711. PMID:20124414

Smith TK, Vasileva N, Gluenz E, Terry S, Portman N, Kramer S, Carrington M, Michaeli S, Gull K, Rudenko G. (2009)Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. PLoS ONE 4: e7532. PMID:19855834

Kramer S, Queiroz R, Ellis L, Webb H, Hoheisel JD, Clayton C, Carrington M. (2008)Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci 121: 3002-3014. PMID:18713834

Hammarton TC, Kramer S, Tetley L, Boshart M, Mottram JC. (2007)Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis. Molecular microbiology 65: 1229-1248. PMID:17662039

Kelly S, Reed J, Kramer S, Ellis L, Webb H, Sunter J, Salje J, Marinsek N, Gull K, Wickstead B et al.  (2007)Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol 154: 103-109. PMID:17512617

Kramer S, Klöckner T, Selmayr M, Boshart M. (2007)Interstrain sequence comparison, transcript map and clonal genomic rearrangement of a 28 kb locus on chromosome 9 of Trypanosoma brucei. Mol Biochem Parasitol 151: 129-132. PMID:17112605