Lehrstuhl für Zell- und Entwicklungsbiologie

Nicola Jones - full list of publications

Peered reviewed publications

Reuter C, Hauf L, Imdahl F, Sen R, Vafadarnejad E, Fey P, Finger T, Jones NG, Walles H, Barquist L, Saliba AE, Groeber-Becker F, Engstler M (2023). Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms. Nature Communications 14:7660. doi: 10.1038/s41467-023-43437-2.

Hempelmann A, Hartleb L, van Straaten M, Hashemi H, Zeelen JP, Bongers K, Papavasiliou FN, Engstler M, Stebbins CE, Jones NG (2021). Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome. Cell Reports 37:109923. doi: 10.1016/j.celrep.2021.109923.

Borges AR*, Link F*, Engstler M, Jones NG (2021). The Glycosylphosphatidyl Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids. Frontiers in Cell and Developmental Biology 9:720536. doi: 10.3389/fcell.2021.720536.

Bakari-Soale M, Ikenga NJ, Scheibe M, Butter F, Jones NG, Kramer S, Engstler M (2021). The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei. Scientific Reports 11:18325. doi:10.1038/s41598-021-97020-0.

Link F*, Borges AR*, Jones NG, Engstler M (2021). To the Surface and Back: Exo- and Endocytic Pathways in Trypanosoma brucei. Frontiers in Cell and Developmental Biology 9:720521. doi: 10.3389/fcell.2021.720521.

Bartossek T*, Jones NG*, Schäfer C, Cvitković M, Glogger M, Mott HR, Kuper J, Brennich M, Carrington M, Smith A-S, Fenz S, Kisker C, Engstler M (2017). Structural basis for the shielding function of the dynamic trypanosome VSG coat. Nature Microbiology 2:1523-1532. doi: 10.1038/s41564-017-0013-6.

Markert SM, Bauer V, Muenz TS, Jones NG, Helmprobst F, Britz S, Sauer M, Rössler W, Engstler M, Stigloher C (2017). 3D subcellular localization with superresolution array tomography on ultrathin sections of various species. Methods in Cell Biology 140:21-47. doi: 10.1016/bs.mcb.2017.03.004

Zimmermann H, Subota I, Batram C, Kramer S, Janzen C, Jones NG, Engstler M (2017). A Quorum Sensing-independent Path to Stumpy Development in Trypanosoma brucei. Plos Pathogens 13:e1006324. doi: 10.1371/journal.ppat.1006324.


Hartel AJW, Glogger M, Jones NG, Abuillan W, Batram C, Hermann A, Fenz SF, Tanaka M, Engstler M (2016). N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold. Nature Communications 7:12870. doi: 10.1038/ncomms12870.

Hartel AJW, Glogger M, Guigas G, Jones NG, Fenz SF, Weiss M, Engstler M (2015). The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane. Scientific Reports 5:10394. doi: 10.1038/srep10394.

Batram C, Jones NG, Janzen CJ, Markert SM, Engstler M (2014). Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei. eLife 3:e02324. doi: 10.7554/eLife.02324.

Abuillan W, Vorobiev A, Hartel A, Jones NG, Engstler M, Tanaka M (2012). Quantitative determination of the lateral density and intermolecular correlation between proteins anchored on the membrane surfaces using grazing incidence small-angle X-ray scattering and grazing incidence X-ray fluorescence. The Journal of Chemical Physics 137:204907. doi: 10.1063/1.4767569.

Harrington JM, Scelsi C, Hartel A, Jones NG, Engstler M, Capewell P, MacLeod A, Hajduk S (2012). Novel African Trypanocidal Agents: Membrane Rigidifying Peptides. PLoS ONE 7:e44384. doi: 10.1371/journal.pone.0044384.

Hiltensperger G, Jones NG, Niedermeier S, Stich A, Kaiser M, Jung J, Puhl S, Damme A, Braunschweig H, Meinel L, et al. (2012). Synthesis and Structure-Activity Relationships of New Quinolone-Type Molecules against Trypanosoma brucei. Journal of Medicinal Chemistry 55:2538-2548. doi: 10.1021/jm101439s.

Schwede A, Jones N, Engstler M, Carrington M (2011). The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes. Molecular and Biochemical Parasitology 175:201-204. doi: 10.1016/j.molbiopara.2010.11.004.

Field MC, Lumb JH, Adung’a VO, Jones NG, Engstler M (2009). Macromolecular trafficking and immune evasion in African trypanosomes. International Review of Cell and Molecular Biology 278:1-67. doi: 10.1016/S1937-6448(09)78001-3.

Jones NG, Nietlispach D, Sharma R, Burke DF, Eyres I, Mues M, Mott HR, Carrington M (2008). Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein. The Journal of Biological Chemistry 283:3584-3593. doi: 10.1074/jbc.M706207200.

Marcello L, Menon S, Ward P, Wilkes JM, Jones NG, Carrington M, Barry JD (2007). VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins. BMC Bioinformatics 8:143. doi: 10.1186/1471-2105-8-143.

Hutchinson OC, Picozzi K, Jones NG, Mott H, Sharma R, Welburn SC, Carrington M (2007). Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. BMC Genomics 8:234. doi: 10.1186/1471-2164-8-234.

Chattopadhyay A, Jones NG, Nietlispach D, Nielsen PR, Voorheis HP, Mott HR, Carrington M (2005). Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2. The Journal of Biological Chemistry 280:7228-7235. doi: 10.1074/jbc.M410787200.

Barry JD, Marcello L, Morrison LJ, Read AF, Lythgoe K, Jones N, Carrington M, Blandin G, Böhme U, Caler E, et al. (2005). What the genome sequence is revealing about trypanosome antigenic variation. Biochemical Society Transactions 33:986-989. doi: 10.1042/BST0330986.

Kamp G, Busselmann G, Jones N, Wiesner B, Lauterwein J (2003). Energy metabolism and intracellular pH in boar spermatozoa. Reproduction (Cambridge, England) 126:517-525. doi: 10.1530/rep.0.1260517.

Hutchinson OC, Smith W, Jones NG, Chattopadhyay A, Welburn SC, Carrington M (2003). VSG structure: similar N-terminal domains can form functional VSGs with different types of C-terminal domain. Molecular and Biochemical Parasitology 130, 127-131. doi: 10.1016/S0166-6851(03)00144-0.

Bone W, Jones NG, Kamp G, Yeung CH, Cooper TG (2000). Effect of ornidazole on fertility of male rats: inhibition of a glycolysis-related motility pattern and zona binding required for fertilization in vitro. Journal of Reproduction and Fertility 118, 127-135. doi: 10.1530/jrf.0.1180127


Bakari-Soale M, Batram C, Zimmermann H, Jones NG, Engstler M (2023). The dual role of the 16mer motif within the 3' untranslated region of the variant surface glycoprotein of Trypanosoma brucei. Preprint: bioRxiv. doi: 10.1101/2023.12.21.52740.


Link F, Borges A, Karo O, Jungblut M, Müller T, Meyer-Natus E, Krüger T, Sachs S Jones NG, Morphew M, Sauer M, Stigloher C, McIntosh JR, Engstler M (2023). Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes. Preprint: bioRxiv. doi: 10.1101/2023.07.20.549860.

Bakari-Soale M, Ikenga NJ, Scheibe M, Butter F, Jones NG, Kramer S, Engstler M (2021). The Nucleolar DExD/H Protein Hel66 is Involved in Ribosome Biogenesis in Trypanosoma brucei. Preprint: bioRxiv. doi: 10.1101/2021.06.11.448066.

Aroko EO, Bakari Soale M, Batram C, Jones NG, Engstler M (2021). Endoplasmic reticulum-targeting but not translation is required for mRNA balancing in trypanosomes. Preprint: bioRxiv. doi: 10.1101/2021.05.05.442555.

Hempelmann A, Hartleb L, van Straaten M, Hashemi H, Zeelen JP, Papavasiliou FN, Engstler M, Stebbins CE, Jones NG (2021). Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome. Preprint: bioRxiv. doi: 10.1101/2021.01.13.426364.